5′,6′-Epoxyeicosatrienoic acid can mobilizes calcium in anterior pituitary cells, stimulates insulin in rat pancreatic islets, and a potent stimulator of prolactin secretion. 5′,6′-Epoxyeicosatrienoic acid is also a potent vasodilator in the intestinal and cerebral microcirculation as well as in bovine coronary arteries. This compound is an endogenous TRPV4 agonist (Ki= 150nM).
For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. After opening, prepare aliquots and store at -80°C. Protect from air.
A solution in methyl acetate
Soluble in 100% ethanol (50 mg/ml), DMSO, DMF, and PBS, pH 7.2 (1 mg/ml).
Store at -80° C
n20D 1.50 (Predicted)
TRPV4: Ki= 150 nM
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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What is the exact volume of the sample of 50 micrograms of 5',6'-Epoxyeicosatrienoic acid? Since it comes in a solution of methyl acetate, I would like to know the exact volume to calculate my dilutions.
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