Cyp2c69 Activators
Cyp2c69, a cytochrome P450 enzyme, exhibits diverse functions, including caffeine oxidase, heme binding, and monooxygenase activities. Predicted to be involved in the epoxygenase P450 pathway and xenobiotic metabolic processes, Cyp2c69 plays a crucial role in cellular processes. Located in the cytoplasm and intracellular membrane-bounded organelles, Cyp2c69 has been implicated in diseases such as Plasmodium falciparum malaria, eosinophilic esophagitis, glucose metabolism diseases, invasive aspergillosis, and multiple chemical sensitivity. As an ortholog of CYP2C19 and CYP2C9, Cyp2c69 is part of the cytochrome P450 family.
Activation of Cyp2c69 involves both direct and indirect mechanisms mediated by various chemicals. Direct activators, such as Phenobarbital, Metformin, and Gemfibrozil, upregulate Cyp2c69 expression, stimulating caffeine oxidase and monooxygenase activities. Indirect activators, like N-acetylcysteine, Fisetin, and Ursolic Acid, modulate the Keap1/Nrf2 pathway, enhancing Cyp2c69 expression and activity. The general mechanisms of activation revolve around the modulation of Cyp2c69 expression and function through cytochrome P450 and Keap1/Nrf2 pathways, contributing to its crucial role in xenobiotic metabolism and cellular processes. Understanding these activators provides insights into potential strategies for manipulating Cyp2c69 activity in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride serves as a direct activator of Cyp2c69, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin, a flavonoid, indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid, a natural compound, indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil serves as a direct activator of Cyp2c69, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $42.00 | 8 | |
Ciprofloxacin is a direct activator of Cyp2c69, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural compound, indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Chlorzoxazone | 95-25-0 | sc-211078 | 10 mg | $61.00 | ||
Chlorzoxazone serves as a direct activator of Cyp2c69, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein, a flavonoid, indirectly activates Cyp2c69 by modulating the Keap1/Nrf2 pathway. It upregulates the expression of Cyp2c69, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||