CYP2B13 Activators
CYP2B13, a member of the cytochrome P450 family, plays a crucial role in various physiological processes, including the metabolism of xenobiotics and endogenous compounds. This enzyme is primarily expressed in the liver and is known for its involvement in the epoxygenase P450 pathway, steroid metabolism, and xenobiotic catabolism. CYP2B13's significance is underscored by its implication in diseases such as acute myeloid leukemia, HIV infectious disease, and tuberculosis.
The activation of CYP2B13 is intricately regulated by various chemicals that act as direct or indirect activators. Direct activators, such as Phenobarbital and 3-Methylcholanthrene, modulate the enzyme by engaging specific nuclear receptors like CAR and AhR. Indirect activators, like Rifampicin and Dexamethasone, stimulate the expression of CYP2B13 through activation of nuclear receptors PXR and glucocorticoid receptor, respectively. These inductions lead to increased transcription, thereby enhancing the metabolic activity of CYP2B13. The involvement of AhR, PXR, and other regulatory pathways illustrates the complexity of CYP2B13 activation, highlighting its role as a central player in cellular homeostasis and xenobiotic metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
Acting as an aryl hydrocarbon receptor (AhR) agonist, 3-Methylcholanthrene activates AhR, which subsequently induces CYP2B13 expression through the AhR/ARNT heterodimeric complex. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, a potent inducer of the nuclear receptor PXR, stimulates CYP2B13 transcription. PXR activation leads to increased expression of CYP2B13, enhancing its metabolic activity. | ||||||
Aroclor 1254 | 11097-69-1 | sc-257096 | 50 mg | $143.00 | 1 | |
Aroclor 1254, a polychlorinated biphenyl, activates the AhR pathway, indirectly upregulating CYP2B13 expression through AhR-mediated transcriptional regulation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid receptor agonist, induces CYP2B13 expression through glucocorticoid receptor activation, leading to increased transcription and enzyme activity. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
As an AhR agonist, β-Naphthoflavone stimulates CYP2B13 expression through AhR-mediated signaling, influencing transcription and subsequent enzyme activation. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole activates PXR, leading to enhanced CYP2B13 expression. PXR-induced transcriptional upregulation is the mechanism through which omeprazole promotes the enzyme's activity. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate, a PPARα agonist, induces CYP2B13 expression through PPARα activation, resulting in increased transcription and subsequent upregulation of the enzyme. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole activates PXR, leading to increased CYP2B13 expression. PXR-mediated transcriptional upregulation is the mechanism through which clotrimazole enhances the enzyme's activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly upregulates CYP2B13 by inhibiting histone deacetylases, promoting a chromatin structure that facilitates increased transcription and subsequent enzyme activity. | ||||||