cyclin M1 Inhibitors
Chemical inhibitors of cyclin M1 target various ion transport and regulatory mechanisms that the protein is involved in. Ouabain and digoxin, both cardiac glycosides, inhibit the Na+/K+-ATPase pump, which is essential for maintaining the electrochemical gradient across the cell membrane. By inhibiting this pump, the intracellular environment is altered, particularly the ion concentration, which cyclin M1 is known to regulate. Consequently, the inhibition of the Na+/K+-ATPase pump can lead to an indirect inhibition of cyclin M1 by disrupting the ion homeostasis that is crucial for its regulatory function. Similarly, amiloride and its analog benzamil, as well as phenamil, selectively inhibit the epithelial sodium channels (ENaCs). These channels are pivotal in maintaining sodium balance within the cells. Cyclin M1, which has a role in ion transport, can be indirectly inhibited when the function of ENaCs is suppressed, leading to a disturbance in sodium homeostasis that cyclin M1 helps to maintain.
Calcium channel blockers such as verapamil, diltiazem, and nifedipine, alter calcium ion influx into cells. Cyclin M1's function is closely related to the regulation of ion transport, and by inhibiting calcium channels, these drugs can indirectly affect cyclin M1 activity by disrupting the calcium ion balance. The altered calcium homeostasis can thus impede the regulatory role of cyclin M1. Potassium-sparing diuretics such as spironolactone, triamterene, canrenone, and eplerenone antagonize the effects of aldosterone or block sodium channels, leading to changes in potassium and sodium balance in the body. These alterations in ion concentrations and transport can indirectly inhibit cyclin M1 by modifying the ion equilibrium, which is under the regulatory scope of cyclin M1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a cardiac glycoside that inhibits Na+/K+-ATPase. Because cyclin M1 is implicated in cellular ion regulation, ouabain's inhibition of this pump could indirectly inhibit cyclin M1 by disrupting ion balances that cyclin M1 may regulate. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a diuretic that acts as a selective inhibitor of epithelial sodium channels (ENaCs). Cyclin M1 is linked to magnesium and other ion transport; inhibition of ion channels by amiloride could disrupt ion homeostasis, leading to an indirect inhibition of cyclin M1's regulatory function on these ions. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone is a potassium-sparing diuretic known to antagonize aldosterone receptors. It might indirectly reduce the activity of cyclin M1 by altering the ion exchange and transport mechanisms that cyclin M1 is potentially involved in. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin, another cardiac glycoside, inhibits the Na+/K+-ATPase pump, which could lead to an indirect downregulation of cyclin M1 activity due to altered ion homeostasis, which cyclin M1 is suggested to influence. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that could indirectly inhibit cyclin M1 by altering calcium homeostasis, which could affect the regulatory role of cyclin M1 in cellular ion channels involved in calcium transport. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is another calcium channel blocker that may inhibit cyclin M1 indirectly by disrupting calcium ion balance in the cell, potentially affecting the regulation of ion transport by cyclin M1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a calcium channel blocker, could decrease calcium ion influx, indirectly inhibiting cyclin M1 by affecting calcium ion homeostasis, which is a process that cyclin M1 may help to regulate. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Triamterene is a potassium-sparing diuretic that blocks sodium channels. By disrupting sodium reabsorption, triamterene could indirectly inhibit cyclin M1 by affecting the ion homeostasis that cyclin M1 is involved in. | ||||||
Benzamil•HCl | 161804-20-2 | sc-201070 | 50 mg | $195.00 | 1 | |
Benzamil is closely related to amiloride and acts as an ENaC inhibitor. By inhibiting sodium channels, benzamil could disrupt ion homeostasis and indirectly inhibit the function of cyclin M1. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $108.00 $612.00 | 4 | |
Eplerenone is an aldosterone antagonist that could indirectly inhibit cyclin M1 by interfering with the regulation of ion transport and signaling pathways that cyclin M1 is known to affect. | ||||||