Eplerenone (CAS 107724-20-9)
See product citations (4)
QUICK LINKS
Eplerenone is a selective mineralocorticoid receptor antagonist that functions by competitively binding to the mineralocorticoid receptor, blocking the binding of aldosterone. This interaction prevents the activation of mineralocorticoid receptors in the kidney, heart, blood vessels, and brain. At the molecular level, eplerenone′s mechanism of action involves disrupting the signaling pathways mediated by aldosterone, ultimately leading to the modulation of ion transport and the regulation of blood pressure and electrolyte balance. Eplerenone′s function in experimental applications involves its ability to selectively target and inhibit the mineralocorticoid receptor, providing insights into the role of aldosterone in various physiological processes.
Eplerenone (CAS 107724-20-9) References
- Eplerenone: a selective aldosterone receptor antagonist for hypertension and heart failure. | Moore, TD., et al. 2003. Heart Dis. 5: 354-63. PMID: 14503934
- Eplerenone: a new selective aldosterone receptor antagonist. | Weinberger, MH. 2004. Drugs Today (Barc). 40: 481-5. PMID: 15349128
- Eplerenone: selective aldosterone antagonism in management of cardiovascular and renal disease. | Brennan, BJ. and Martin, NE. 2004. J Am Pharm Assoc (2003). 44: 604-10; quiz 610-1. PMID: 15496047
- Eplerenone in hypertension. | Burgess, E. 2004. Expert Opin Pharmacother. 5: 2573-81. PMID: 15571474
- Eplerenone: a selective aldosterone receptor antagonist for patients with heart failure. | Barnes, BJ. and Howard, PA. 2005. Ann Pharmacother. 39: 68-76. PMID: 15590870
- Eplerenone after myocardial infarction? | . 2008. Drug Ther Bull. 46: 1-3. PMID: 18171726
- A comparison of the aldosterone-blocking agents eplerenone and spironolactone. | Struthers, A., et al. 2008. Clin Cardiol. 31: 153-8. PMID: 18404673
- Eplerenone's role in the management of complex cardiovascular disorders. | Stewart Coats, AJ. and Shewan, L. 2015. Int J Cardiol. 200: 1-2. PMID: 26116081
- Eplerenone for hypertension. | Tam, TS., et al. 2017. Cochrane Database Syst Rev. 2: CD008996. PMID: 28245343
- Eplerenone Versus Spironolactone in Resistant Hypertension: an Efficacy and/or Cost or Just a Men's Issue? | Manolis, AA., et al. 2019. Curr Hypertens Rep. 21: 22. PMID: 30826898
- Eplerenone repurposing in management of chorioretinopathy: Mechanism, nanomedicine-based delivery applications and future trends. | Abdelhakeem, E., et al. 2022. Br J Clin Pharmacol. 88: 2665-2672. PMID: 34983084
- Eplerenone inhibits UUO-induced lymphangiogenesis and cardiac fibrosis by attenuating inflammatory injury. | Chen, G., et al. 2022. Int Immunopharmacol. 108: 108759. PMID: 35428023
- Effect of eplerenone on clinical stability of Japanese patients with acute heart failure. | Kobayashi, M., et al. 2023. Int J Cardiol. 374: 73-78. PMID: 36586516
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eplerenone, 10 mg | sc-203943 | 10 mg | $110.00 | |||
Eplerenone, 50 mg | sc-203943A | 50 mg | $624.00 |