CYBASC3 Activators
Cytochrome b561 family member A3 (CYB561A3), also known as duodenal cytochrome b (Dcytb), is a transmembrane protein that belongs to the cytochrome b561 family of proteins. These proteins are characterized by their heme-binding domains and their role in electron transfer across cellular membranes. CYB561A3 is specifically known for its function in the reduction of ferric to ferrous iron at the brush border of the duodenum, which is an essential step in dietary iron absorption.
CYB561A3 utilizes ascorbate (vitamin C) as an electron donor to reduce iron, which is then transported into the cell by divalent metal transporter 1 (DMT1). This process is vital for maintaining iron homeostasis in the body and blcoking conditions such as anemia. The protein is expressed on the apical surface of enterocytes in the duodenum, which is the primary site for iron absorption.The activity of CYB561A3 is tightly regulated by the body's iron needs, with expression levels responding to iron stores and demand. When iron levels are low, the body upregulates proteins like CYB561A3 to increase iron absorption. Conversely, when iron is abundant, the expression of CYB561A3 is reduced to blocking excess iron accumulation, which can be toxic.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
May upregulate CYB561A3 to enhance electron transfer for ascorbate regeneration. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $43.00 $62.00 $141.00 | ||
As an antioxidant, it might increase the need for CYB561A3 in combating oxidative stress. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Could upregulate CYB561A3 to maintain redox homeostasis. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
May induce CYB561A3 expression by acting as a precursor to glutathione. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Might enhance CYB561A3 expression due to its role in oxidative stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Could upregulate CYB561A3 through its antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
May induce CYB561A3 as part of a cellular protective response against oxidative damage. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Could stimulate CYB561A3 expression due to its role in modulating oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Might upregulate CYB561A3 as it is involved in cellular antioxidant defense mechanisms. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $43.00 $63.00 $156.00 $563.00 $1008.00 | 10 | |
May induce CYB561A3 expression by enhancing antioxidant activity. | ||||||