CYB5R2 Inhibitors
Chemical compounds classified as CYB5R2 inhibitors exert their influence by directly or indirectly preventing the reduction of cytochrome b5, a crucial step in the electron transport processes where CYB5R2 is involved. Plumbagin and menadione act by either competing with NADH at the enzyme's binding site or by inducing NADH depletion, respectively, leading to decreased CYB5R2 activity. Similarly, diphenyleneiodonium chloride and thioridazine can bind to the flavin group of CYB5R2 or affect the enzyme's electron transfer capability, leading to functional inhibition. Aurachin D and coenzyme Q0 may bind to sites on CYB5R2 that are essential for its interaction with cytochrome b5 or compete with natural ubiquinone, thus impeding the enzyme's activity.
Other inhibitors such as methylene blue and phenazine methosulfate can act as redox mediators, competing with CYB5R2 for its electron donors or acceptors. This competition alters the normal flow of electrons within the cell and can lead to a decrease in cytochrome b5 reduction. Capsazepine, while not a direct inhibitor, may affect mitochondrial function, which could result in less NADH being available for CYB5R2, indirectly reducing its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Plumbagin is a naphthoquinone that can inhibit the NADH-dependent electron transfer activity of CYB5R2 by competing with NADH for the enzyme's binding site. This action directly decreases the electron transfer capabilities of CYB5R2, reducing its functionality in cellular redox reactions. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Menadione, a vitamin K3 analog, can undergo redox cycling and in the process, sequester electrons from CYB5R2, leading to its functional inhibition by depleting the enzyme of its reducing equivalents necessary for its activity. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
Diphenyleneiodonium chloride (DPI) is a flavoenzyme inhibitor that can inactivate CYB5R2 by binding to its flavin cofactor, thus blocking the electron transport chain in which CYB5R2 participates. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene blue is a phenothiazine dye that can act as both an electron donor and acceptor. It can interfere with CYB5R2's activity by accepting electrons that would normally be transferred to CYB5R2's natural electron acceptors, thereby inhibiting its function. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine, a vanilloid receptor antagonist, has been shown to interfere with electron transfer proteins. It could inhibit CYB5R2 by altering the redox state of the enzyme, preventing it from catalyzing electron transfer reactions efficiently. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $26.00 $55.00 $82.00 $336.00 | 2 | |
Imidazole is known to bind to heme-containing proteins. By binding to the heme group of CYB5R2, it can inhibit the enzyme's ability to transfer electrons, thereby decreasing its activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, an antimalarial drug, can intercalate in DNA and has been shown to inhibit various enzymes. It could inhibit CYB5R2 by interfering with the enzyme's structure, leading to impaired electron transfer capability. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine, a phenothiazine antipsychotic, can inhibit flavoproteins and might inhibit CYB5R2 by binding to its flavin cofactor, thus interfering with its electron transfer function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that exhibits a broad range of biochemical effects, including the inhibition of various enzymes. It could inhibit CYB5R2 by binding to the enzyme's active site or altering its conformation, which would decrease its electron transfer ability. | ||||||