CUEDC2 Activators
The chemical class known as CUEDC2 Activators encompasses a group of compounds that have the potential to indirectly influence the activity or function of CUEDC2 (CUE domain-containing 2), a protein involved in various cellular processes, including the regulation of ubiquitination and protein degradation.
One strategy employed by CUEDC2 activators is the inhibition of proteasomal degradation, a process critical for the turnover of ubiquitinated proteins. Compounds such as MG-132 and Lactacystin, both proteasome inhibitors, play a pivotal role in this regard. By preventing the degradation of proteins tagged for ubiquitination, these compounds indirectly stabilize the interactions between CUEDC2 and ubiquitinated proteins, potentially enhancing CUEDC2-mediated regulatory functions within the ubiquitin-proteasome system. Additionally, CUEDC2 activators include chemicals like AICAR and Rapamycin, which act on upstream signaling pathways. AICAR activates AMP-activated protein kinase (AMPK), influencing cellular energy levels and the ubiquitination of specific protein substrates. Rapamycin, on the other hand, inhibits the mTOR pathway, a central regulator of protein synthesis and degradation. Through the suppression of mTOR, Rapamycin indirectly impacts CUEDC2-mediated processes related to protein turnover.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that indirectly affects CUEDC2 by preventing the degradation of proteins targeted for ubiquitination. CUEDC2 may interact with ubiquitinated proteins, and MG-132 can stabilize these interactions. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK). AMPK activation can indirectly influence CUEDC2 by regulating cellular energy levels and the ubiquitination of specific protein substrates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a role in protein synthesis and degradation. By suppressing mTOR, rapamycin can indirectly affect CUEDC2-mediated processes related to protein turnover. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor that, similar to MG-132, indirectly influences CUEDC2 by preventing proteasomal degradation, thereby stabilizing ubiquitinated proteins that CUEDC2 may interact with. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is a histone deacetylase (HDAC) inhibitor. It can indirectly impact CUEDC2 by modulating protein acetylation and potentially affecting the stability of CUEDC2-interacting proteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to affect lysosomal function. Alterations in lysosomal dynamics can indirectly influence CUEDC2-mediated processes involved in protein degradation and turnover. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor used in cancer research. It indirectly affects CUEDC2 by preventing the degradation of ubiquitinated proteins that CUEDC2 may interact with. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxyglucose interferes with glycolytic processes and energy metabolism. Changes in cellular energy availability may indirectly affect CUEDC2-mediated processes, including protein degradation pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate AMPK and SIRT1. These activations can indirectly impact CUEDC2 by modulating cellular energy levels and protein acetylation, potentially affecting protein turnover. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By interfering with PI3K-related signaling pathways, wortmannin can indirectly influence CUEDC2-mediated processes related to protein ubiquitination and degradation. | ||||||