CTPS1 Activators
The chemical class of CTPS1 activators encompasses a range of compounds that indirectly influence the activity of CTP Synthase 1 through various pathways related to nucleotide metabolism. These activators include both nucleotide analogs and compounds affecting nucleotide synthesis pathways, highlighting the interconnected nature of nucleotide metabolism and the potential for indirect modulation of CTPS1 activity. Compounds such as uridine triacetate, 5-fluorouracil, and 6-azauridine are notable in this class for their roles in pyrimidine metabolism. Their presence can alter the balance of nucleotide pools, potentially leading to compensatory mechanisms that increase CTPS1 activity. This indirect effect demonstrates the delicate balance within nucleotide synthesis pathways and the potential for external compounds to influence enzyme activity through alterations in substrate availability and metabolic demand.
Additionally, drugs affecting purine metabolism, such as azathioprine, mycophenolate mofetil, and allopurinol, also play a significant role in this class. By impacting purine synthesis, these compounds can indirectly influence CTPS1 activity. The changes in nucleotide pools and metabolic feedback mechanisms resulting from their action can lead to altered CTPS1 activity, emphasizing the complex regulation of nucleotide synthesis and the potential for indirect modulation of specific enzymes within these pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2′,3′,5′-Tri-O-acetyluridine | 4105-38-8 | sc-216312A sc-216312 sc-216312B sc-216312C sc-216312D sc-216312E | 1 g 5 g 25 g 100 g 500 g 1 kg | $21.00 $34.00 $64.00 $190.00 $883.00 $1436.00 | ||
As a uridine analog, uridine triacetate can influence pyrimidine metabolism, potentially increasing CTPS1 activity by altering nucleotide pool balances. | ||||||
Ammonium Sulfate | 7783-20-2 | sc-29085A sc-29085 sc-29085B sc-29085C sc-29085D sc-29085E | 500 g 1 kg 2 kg 5 kg 10 kg 22.95 kg | $11.00 $21.00 $31.00 $41.00 $61.00 $102.00 | 9 | |
Ammonium ions are substrates for glutamine synthetase, which plays a role in nitrogen metabolism. Altered nitrogen metabolism can indirectly affect CTPS1 activity by modulating glutamine availability. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog that disrupts thymidylate synthesis. Its influence on pyrimidine metabolism can indirectly affect CTPS1 activity by altering nucleotide pools. | ||||||
6-Azauridine | 54-25-1 | sc-221082B sc-221082 sc-221082C sc-221082A | 500 mg 1 g 2 g 5 g | $97.00 $159.00 $295.00 $679.00 | ||
An uridine analog that interferes with pyrimidine metabolism, potentially leading to altered CTPS1 activity as a response to changes in nucleotide pools. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
An immunosuppressive drug that affects purine metabolism. Its impact on nucleotide synthesis pathways can indirectly influence CTPS1 activity. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Inhibits inosine monophosphate dehydrogenase, leading to decreased guanine synthesis, which may indirectly influence CTPS1 activity due to changes in nucleotide balance. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
An antiviral drug that affects nucleotide metabolism, potentially influencing CTPS1 activity indirectly through its impact on nucleotide pools. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
A xanthine oxidase inhibitor affecting purine metabolism, which could indirectly influence CTPS1 activity due to shifts in nucleotide synthesis pathways. | ||||||