CTF18 Inhibitors
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Items 1 to 10 of 23 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Interferes with the ATR-CHK1 pathway, essential for CTF18 complex recruitment to replicating chromatin, thereby indirectly inhibiting CTF18 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate downstream targets that enhance the activity of 1810029B16Rik by promoting its cellular functions. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
Targets CHK1, a downstream effector in the ATR pathway, which is also requisite for CTF18 function during DNA replication and damage response. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor. By selectively inhibiting kinases that negatively regulate 1810029B16Rik, it can lead to an enhanced activity of 1810029B16Rik through derepression. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
CDKs are involved in cell cycle regulation, and the inhibition of certain CDKs can disrupt processes that require CTF18, such as sister chromatid cohesion. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This influx can activate calcium-dependent kinases, which can then enhance the activity of 1810029B16Rik through phosphorylation of proteins in the related pathways. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
Impedes the ATM kinase, which is involved in the DNA damage response, a process in which CTF18 has a role; thus, indirectly affects CTF18's function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is also a calcium ionophore, similar to Ionomycin. It increases intracellular calcium concentration, thereby activating calcium-dependent signaling pathways that may enhance the functional activity of 1810029B16Rik. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to enhanced 1810029B16Rik activity through downstream signaling pathways that 1810029B16Rik is involved in. | ||||||
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one | 955365-80-7 | sc-483196 | 5 mg | $340.00 | 1 | |
By inhibiting WEE1 kinase, it disrupts the cell cycle checkpoint control, potentially impacting CTF18's role in the DNA damage checkpoint. | ||||||