CTF18 Activators
The chemical class known as CTF18 Activators includes agents that specifically target and modulate the activity of the CTF18 protein, a key element in cellular DNA replication and maintenance. CTF18, part of the CTF18-RFC (CTF18-Replication Factor C) complex, is essential for maintaining chromosome transmission fidelity, particularly during cell division. This protein complex is crucial in responding to DNA replication stress, facilitating DNA repair mechanisms, and ensuring chromosome cohesion. Activators within this class are designed to enhance either the expression or functional activity of CTF18, thereby influencing these critical cellular processes. The action mechanisms of these activators are diverse, reflecting the multifaceted roles of CTF18 in cellular function. Some may function by upregulating the transcription of the CTF18 gene, potentially through epigenetic modifications that increase gene accessibility. Others might stabilize CTF18 mRNA, improving its translation efficiency. Additionally, certain activators could directly interact with the CTF18 protein or its associated complex, enhancing its stability or interaction with other cellular molecules.
CTF18 Activators are of significant interest due to their ability to influence fundamental aspects of cell biology. By targeting CTF18, these chemicals provide insights into the processes of DNA replication fidelity and genomic stability. Their primary application is seen in basic biological research, where they can be used to dissect the complex mechanisms of DNA replication, repair, and chromosome maintenance. Additionally, these activators might be valuable in studying how cells handle replication stress, a key factor in understanding cellular aging, genomic instability, and cell division mechanisms. As such, CTF18 Activators represent an important area of scientific exploration, offering the potential to illuminate the essential processes that underpin cellular life and ensure genomic integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May induce CTF18 by inhibiting DNA methylation, leading to the activation of silenced genes including those involved in DNA repair and replication. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As an HDAC inhibitor, it might upregulate CTF18 by increasing histone acetylation and thus enhancing gene expression related to DNA damage response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Could potentially increase CTF18 expression by modulating cell signaling pathways, particularly those related to cell growth and stress response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
May indirectly upregulate CTF18 in response to DNA damage caused by its action as a topoisomerase inhibitor. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Might enhance CTF18 expression through its role in activating SIRT1, influencing DNA repair mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Could upregulate CTF18 by modulating NF-kB pathway, which is involved in cellular stress response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, it may increase the expression of CTF18 by altering chromatin structure and gene expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Might induce CTF18 expression as part of the cellular response to DNA cross-link damage it causes. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Could potentially increase CTF18 due to its role in inducing DNA damage and subsequent DNA repair pathways. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
May upregulate CTF18 in response to replication stress induced by its inhibition of ribonucleotide reductase. | ||||||