CTDSPL2 Activators
CTDSPL2, standing for CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2, is a protein encoded by the CTDSPL2 gene in humans. It belongs to the family of small C-terminal domain phosphatases, which are involved in various cellular processes, especially in the regulation of RNA polymerase II.
One of the primary roles of CTDSPL2 is the regulation of RNA polymerase II activity. RNA polymerase II is crucial for the transcription of mRNA and some small RNAs. CTDSPL2 modulates its function by dephosphorylating the C-terminal domain (CTD) of RNA polymerase II. This dephosphorylation is a vital process in the transcription cycle, affecting the initiation, elongation, and termination phases of transcription.CTDSPL2 also has implications in cell differentiation and development. It has been observed to play a role in the differentiation of certain cell types, although the specific mechanisms and pathways it influences are not fully understood. This function is particularly relevant in the context of stem cell biology and tissue regeneration.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, it can alter gene expression patterns, potentially affecting CTDSPL2-regulated genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, affecting chromatin structure and potentially influencing CTDSPL2-mediated transcription. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
An inhibitor of cyclin-dependent kinases, Flavopiridol can affect RNA polymerase II phosphorylation, potentially impacting CTDSPL2. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
An inhibitor of RNA polymerase II transcription, DRB can indirectly affect CTDSPL2 activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent inhibitor of RNA polymerase II, α-Amanitin can influence transcription processes involving CTDSPL2. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Known to affect various signaling pathways, Betulinic Acid may indirectly impact CTDSPL2's function in transcription. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, JQ1 can influence chromatin accessibility and potentially CTDSPL2's transcriptional regulation. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
An HDAC3-specific inhibitor, RGFP966 can affect chromatin structure, potentially influencing CTDSPL2 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another HDAC inhibitor, Vorinostat can impact chromatin remodeling and potentially affect CTDSPL2 function. | ||||||