CTAGE1 Inhibitors
Chemical inhibitors of CTAGE1 can function through various mechanisms to disturb the normal cellular processes in which CTAGE1 is involved, particularly those related to cell cycle progression and mitosis. Alisertib, functioning as an Aurora A kinase inhibitor, disrupts the mitotic processes by preventing the proper phosphorylation and activation of proteins required for cell division, thus indirectly leading to the inhibition of CTAGE1, which operates within these pathways. Similarly, ZM447439 and Volasertib target Aurora B kinase and Polo-like kinase 1 (Plk1) respectively, both of which are critical for chromosome alignment, segregation, and spindle assembly during mitosis. By inhibiting these kinases, the compounds cause errors in cell division, leading to a functional blockade at stages where CTAGE1 activity is critical. Paclitaxel (Taxol), by stabilizing microtubules, prevents their proper disassembly, an essential step for cell division, which results in mitotic arrest and, consequently, the inhibition of CTAGE1 function.
Another set of chemicals, including Monastrol and S-Trityl-L-cysteine, specifically target kinesin Eg5, a motor protein that is vital for the formation of bipolar spindles, and their inhibition results in monopolar spindle formation, which disrupts mitosis and inhibits CTAGE1's role in this process. Proteasome inhibitors like Marizomib, Bortezomib, and MG132 prevent the degradation of proteins marked for destruction by polyubiquitination. This proteasome blockade leads to the accumulation of such proteins, causing cell cycle arrest at various points where CTAGE1 is essential. Nocodazole, a microtubule depolymerizing agent, inhibits the dynamics of microtubules, leading to the inhibition of CTAGE1 by preventing the cell from successfully completing mitosis. Lastly, Purvalanol A, a cyclin-dependent kinase inhibitor, impedes the progression of the cell cycle by inhibiting CDKs, leading to a halt in the cell cycle at phases dependent on CTAGE1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora A kinase inhibitor. Aurora A kinase is known to be involved in the mitotic processes, which are crucial for cell division and proliferation. By inhibiting Aurora A kinase, Alisertib can disrupt normal mitotic progression, leading to the functional inhibition of CTAGE1, which is implicated in cell cycle progression. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is another Aurora kinase inhibitor that can inhibit Aurora B kinase. As Aurora B kinase is essential for correct chromosome alignment and segregation, its inhibition can lead to errors in these processes, thereby blocking the cell cycle at a stage that would require CTAGE1 activity. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a potent Plk1 inhibitor. Polo-like kinase 1 (Plk1) plays a significant role in various stages of mitosis. Inhibiting Plk1 can lead to mitotic arrest, which would prevent the progression of the cell cycle where CTAGE1 is involved. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
Volasertib is another Plk1 inhibitor. It prevents the proper formation of the mitotic spindle, which is essential for chromosome segregation during cell division, thus potentially inhibiting CTAGE1 function related to cell cycle progression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which is essential for mitosis. By stabilizing microtubules, it can lead to mitotic arrest, thereby inhibiting the function of CTAGE1 which is supposed to act during cell division. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor. It specifically blocks the function of this kinesin, leading to the formation of monopolar spindles in mitotic cells, which can indirectly inhibit CTAGE1 by disrupting the cellular processes it is involved in. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5, a motor protein essential for bipolar spindle formation in mitosis. By inhibiting Eg5, it can disrupt spindle formation and thus inhibit CTAGE1's role in mitosis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor. It disrupts normal proteasome function, leading to cell cycle arrest and potentially inhibiting CTAGE1's role in the progression of the cell cycle. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. It can lead to the accumulation of proteins that are normally degraded, causing cell cycle arrest and potentially inhibiting CTAGE1's function in the cell cycle. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule depolymerizing agent. It disrupts microtubule dynamics, which are crucial for mitosis, and can lead to cell cycle arrest, thereby inhibiting CTAGE1's function in cell division. | ||||||