Molecular structure of BI 2536, CAS Number: 755038-02-9
BI 2536 (CAS 755038-02-9)
See product citations (8)
Application:
BI 2536 is a Plk inhibitor with efficacy against 32 cancer cell lines
CAS Number:
755038-02-9
Purity:
≥98%
Molecular Weight:
521.66
Molecular Formula:
C28H39N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BI 2536 treatment ranging from 10 nM to 100 nM blocks the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibits of cohesin release from chromosome arms, and induces monopolar spindle formation and other Plk1 dependent processes. BI 2536 treatment leads to the HeLa cells arrested in the G2/M stage. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM.
BI 2536 (CAS 755038-02-9) References
- BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. | Steegmaier, M., et al. 2007. Curr Biol. 17: 316-22. PMID: 17291758
- The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. | Lénárt, P., et al. 2007. Curr Biol. 17: 304-15. PMID: 17291761
- The Plk1 inhibitor BI 2536 temporarily arrests primary cardiac fibroblasts in mitosis and generates aneuploidy in vitro. | Lu, B., et al. 2010. PLoS One. 5: e12963. PMID: 20886032
- Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536. | Peter, B., et al. 2011. Haematologica. 96: 672-80. PMID: 21242189
- BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. | Morales, AG., et al. 2011. Anticancer Drugs. 22: 995-1001. PMID: 21822121
- BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. | Chen, L., et al. 2015. ACS Med Chem Lett. 6: 764-9. PMID: 26191363
- Binding of the anticancer drug BI-2536 to human serum albumin. A spectroscopic and theoretical study. | Fernández-Sainz, J., et al. 2017. J Photochem Photobiol B. 172: 77-87. PMID: 28531794
- BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1. | Gohda, J., et al. 2018. Sci Rep. 8: 3521. PMID: 29476067
- The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells. | Li, Z., et al. 2020. J Cancer. 11: 3274-3287. PMID: 32231733
- Connectivity Mapping Identifies BI-2536 as a Potential Drug to Treat Diabetic Kidney Disease. | Zhang, L., et al. 2021. Diabetes. 70: 589-602. PMID: 33067313
- Calibrated liposomal release of the anti-mitotic agent BI-2536 increases the targeting of mitotic tumor cells. | Ng, CZ., et al. 2020. Eur J Pharm Biopharm. 157: 183-190. PMID: 33222770
- PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). | Luo, P., et al. 2021. Autophagy. 17: 3221-3237. PMID: 33315519
- BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10. | Hsieh, CH., et al. 2021. Pharmaceuticals (Basel). 15: PMID: 35056094
- Shedding light on the binding mechanism of kinase inhibitors BI-2536, Volasetib and Ro-3280 with their pharmacological target PLK1. | Fernández-Sainz, J., et al. 2022. J Photochem Photobiol B. 232: 112477. PMID: 35644070
- BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer. | Huo, J., et al. 2022. Front Oncol. 12: 963928. PMID: 36016611
Inhibitor of:
2610039C10Rik, 4930534B04Rik, 5830418K08Rik, ANKRD56, APC4, APC5, ASPM, BC024659, BC061194, C16orf63_0610037P05Rik, C17orf55, C1orf96, CCDC34, Cdc10, CENP-F, CENP-O, CENP-R, CENP-T, CENPBD1, CENPVL2, CENPVL3, Centriolin, Centrobin, CLASP (Cytoplasmic Linker Associated Protein), CTAGE1, CTAGE2, CTF18, D2Bwg1423e, D4Wsu53e, DNA pol κ, Dtl, E030010N08Rik, EG244495, EG546272, EG546282, EG633057, Esp1, FAM44B, FAM75A1, FILIA, fzr, GABP-α, H-plk, HAUS3, HAUS5_Haus5, HAX-1, hCAP-G, HEATR6, HYLS1, ING3, INSC, IRF-2BP1, KIAA1009, KIAA1267, KNL2, LGN, MDM1, MEIKIN, MIS12, MKLP-1, Mog1p, Ninein, NuMA, OIP5, Pericentrin 2, Plk, Plk5, POC5, PPAN, PRR19, Ran BP-3L, RCC1, RFWD3, RMP, rotatin, RPA194, SAP 114, scc-112, Sgo1, Sil, Ska1, Snk, SPANX-N1, Speedy E5, Srb10, STK31, TAF II p130, TIM-1, TTDN1, VRK2, WAPL, WDR24, WDR51B, ZNF26, and ZWINT.Activator of:
4930404A10Rik, ANAPC2, APC7, ARP-1, ASPM, AW555464, BC057079, BOB_GPR15, BUB1, BUB3, C10orf104, CCDC53, Cdc26, Cdc5, CdcA1, CENP-E, CENP-I, CENP-M, CENP-N, CENP-T, CENP-V, CEP55, CEP63, CEP72, cyclin J, DSN1, EG231836, EG244495, EG625480, FAM110A, FAM128B, H-plk, HAUS3, HAUS6, Hec1, KIAA0562, KIF15, Kizuna_Plk1s1, MZT1, PWWP2A, Ran BP-10, Sgo2, Spc25, SPDL-1, TACC2, and TTK_Esk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BI 2536, 5 mg | sc-364431 | 5 mg | $151.00 | |||
BI 2536, 50 mg | sc-364431A | 50 mg | $525.00 |