CT45 Activators
Chemical compounds that modulate the activity or expression of CT45 typically involve agents that affect gene expression or cellular signaling pathways. DNA methyltransferase inhibitors like 5-Aza-2′-Deoxycytidine can lead to the reactivation of epigenetically silenced genes, including potentially CT45, by demethylating DNA. This reactivation might enhance the expression of CT45 in tumor cells, making it a more prominent target for immune recognition and therapy. Similarly, histone deacetylase inhibitors such as Trichostatin A and Sodium Butyrate can alter chromatin structure and gene expression profiles, potentially increasing CT45 expression by modifying the acetylation status of histones associated with its gene.
Other compounds like Retinoic Acid, all trans and Cholecalciferol influence cell differentiation and apoptosis, which could indirectly affect CT45's role and expression in various cellular contexts, particularly in tissues where it is aberrantly expressed. Forskolin, through the elevation of cAMP levels, and Rapamycin, as an mTOR inhibitor, represent compounds that alter broader cellular signaling and metabolic pathways, potentially influencing the expression or functional demand for CT45 in processes like cell growth, apoptosis, and response to cellular stress. Lithium Chloride's inhibition of GSK-3β and Curcumin's modulation of inflammation and apoptosis are additional examples of how altering signaling pathways can indirectly impact CT45. Finally, anticancer agents like Hydroxyurea and Temozolomide affect DNA synthesis and repair mechanisms, which might also influence the expression or stability of CT45 as cells respond to DNA damage or replication stress. Collectively, these compounds reflect the potential strategies for indirectly modulating CT45 activity or expression, each contributing to understanding and potentially influencing the role of CT45 in cancer and other diseases where its regulation is of interest.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
As a DNA methyltransferase inhibitor, 5-Aza-2′-Deoxycytidine can lead to the demethylation and reactivation of epigenetically silenced genes, potentially including CT45, thereby enhancing its expression in tumor cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a more relaxed chromatin structure and affect gene expression. It may increase CT45 expression or alter its activity by changing the acetylation status of histones around its gene or regulatory regions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, all trans influences cell differentiation and apoptosis and affects the expression of a wide range of genes. It may influence CT45 activity indirectly by altering cellular differentiation pathways or gene expression profiles. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels and activates PKA, leading to diverse effects on cellular functions and gene expression. It might indirectly affect CT45 activity through these broad cellular changes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects various cellular processes, including inflammation and apoptosis, and might modulate CT45 activity by influencing these pathways or affecting the expression of genes regulated by CT45. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor and can affect gene expression. It might indirectly influence CT45 activity by altering the expression of proteins involved in the signaling pathways where CT45 functions. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to reduced DNA synthesis. It might influence cellular proliferation and stress responses, potentially affecting CT45 expression or function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor affecting cell growth and metabolism. It could potentially influence the cell cycle and DNA damage response pathways, indirectly affecting the role of CT45 in these processes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK-3β, a kinase involved in numerous signaling pathways. By modulating pathways associated with GSK-3β, Lithium Chloride might indirectly affect the signaling context and activity of CT45. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol has roles in cell proliferation, differentiation, and apoptosis. It might affect CT45 activity indirectly by modulating cell cycle dynamics and differentiation status, especially in skin cells. | ||||||