CSMD1 Activators
CSMD1 Activators are specific chemical compounds that directly or indirectly enhance the functional activity of CSMD1. A class of these activators, including GSK-3 inhibitor IX, Lithium chloride, and SB216763, function by inhibiting GSK-3, a kinase involved in a variety of cellular processes. By inhibiting GSK-3, these activators stabilize β-catenin, which can interact with CSMD1 to enhance its functional activity. Other activators, such as PD98059, U0126, LY294002, Wortmannin, and Rapamycin, act by inhibiting kinases involved in important cellular signaling pathways. PD98059 and U0126 are MEK inhibitors that reduce ERK phosphorylation, LY294002 and Wortmannin are PI3K inhibitors that reduce Akt phosphorylation, and Rapamycin is a mTOR inhibitor that reduces S6K phosphorylation. These kinase inhibitors can indirectly activate CSMD1 by influencing the phosphorylation of proteins that can interact with CSMD1, enhancing its functional activity.
Quercetin and Genistein, broad spectrum kinase inhibitors, can indirectly activate CSMD1 by inhibiting multiple kinases, thereby modulating multiple signaling pathways that can interact with CSMD1. Finally, Parthenolide, a NF-κB inhibitor, can indirectly activate CSMD1 by reducing the expression of pro-inflammatory genes. NF-κB plays a crucial role in inflammatory responses, and its inhibition can modulate the activity of CSMD1. By inhibiting NF-κB, Parthenolide can limit the expression of pro-inflammatory genes, some of which may modulate the activity of CSMD1, thereby enhancing its functional activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 inhibitor IX is a potent and selective inhibitor of GSK-3, a kinase involved in a variety of cellular processes. CSMD1 can be indirectly activated by GSK-3 inhibition as it leads to the stabilization of β-catenin, which can interact with CSMD1, enhancing its functional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a GSK-3 inhibitor that can indirectly activate CSMD1. By inhibiting GSK-3, it stabilizes β-catenin, which can interact with CSMD1, enhancing its functional activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is another GSK-3 inhibitor that can indirectly activate CSMD1. Again, by inhibiting GSK-3, it stabilizes β-catenin, which can interact with CSMD1, enhancing its functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a MEK inhibitor that can indirectly activate CSMD1. By inhibiting MEK, it reduces ERK phosphorylation, which can interact with CSMD1, enhancing its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly activate CSMD1. By inhibiting PI3K, it reduces Akt phosphorylation, which can interact with CSMD1, enhancing its functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that can indirectly activate CSMD1. By inhibiting PI3K, it reduces Akt phosphorylation, which can interact with CSMD1, enhancing its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a mTOR inhibitor that can indirectly activate CSMD1. By inhibiting mTOR, it reduces S6K phosphorylation, which can interact with CSMD1, enhancing its functional activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a broad spectrum kinase inhibitor that can indirectly activate CSMD1. By inhibiting multiple kinases, it can modulate multiple signaling pathways that can interact with CSMD1, enhancing its functional activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is another broad spectrum kinase inhibitor that can indirectly activate CSMD1. By inhibiting multiple kinases, it can modulate multiple signaling pathways that can interact with CSMD1, enhancing its functional activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a NF-κB inhibitor that can indirectly activate CSMD1. By inhibiting NF-κB, it reduces the expression of pro-inflammatory genes, which can interact with CSMD1, enhancing its functional activity. | ||||||