cryptdin 26 Activators
Defa26, encoding alpha-defensin 26, emerges as a pivotal player in innate immune responses, engaging in multiple processes crucial for host defense. Predicted to enable protein homodimerization activity, Defa26 is anticipated to be involved in the cellular response to lipopolysaccharide, contributing to the immune system's recognition and defense against bacterial components. Additionally, its role in the defense response to other organisms highlights Defa26's participation in recognizing and combating external threats, emphasizing its significance in the intricate network of innate immunity. The predicted involvement in positive regulation of membrane permeability suggests Defa26's potential role in maintaining cellular integrity and controlling the influx and efflux of substances across membranes, further underscoring its multifunctional nature.
The activation of Defa26 involves a sophisticated interplay of signaling pathways and cellular processes, orchestrating a finely tuned response to microbial challenges. Direct activation through PPARγ receptor modulation, as seen with certain agonists, underscores the importance of transcriptional regulation in Defa26 expression, particularly in the context of the cellular response to lipopolysaccharide. Indirect activators, such as HDAC inhibitors and compounds influencing zinc homeostasis, contribute to Defa26 activation by modulating epigenetic landscapes and cellular processes crucial for defense responses to other organisms. These mechanisms highlight the intricate regulatory network governing Defa26, where the protein's expression and function are finely tuned by various molecular cues. Moreover, the involvement of signaling pathways like JAK/STAT and AMPK further illustrates the complexity of Defa26 activation. Indirect activation through these pathways emphasizes the integration of immune responses with broader cellular signaling cascades, underscoring Defa26's role in connecting innate immunity to cellular homeostasis. The participation of small molecules influencing cell signaling pathways and exhibiting anti-inflammatory effects further emphasizes the multifaceted nature of Defa26 activation, integrating immune responses with broader cellular processes. In summary, Defa26 emerges as a versatile component of the innate immune system, engaged in recognizing microbial threats and orchestrating a precisely regulated defense response through a complex interplay of signaling pathways and cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
PPARγ agonist, directly activating Defa26 by modulating PPARγ receptors. Enhances Defa26 expression through PPARγ-dependent transcription, crucial for cellular response to lipopolysaccharide. Regulates Defa26 involvement in intracellular membrane-bounded organelles and midbody. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Butyrate, an HDAC inhibitor, indirectly activates Defa26 via epigenetic modulation. Induces histone acetylation, upregulating defense response to other organisms. Influences chromatin structure, impacting the extracellular space where Defa26 is active. Promotes expression by affecting the epigenetic landscape and contributing to positive regulation of membrane permeability. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Polyphenolic compound indirectly activates Defa26 through SIRT1 modulation. Enhances expression by influencing processes related to the defense response to other organisms. Promotes Defa26 involvement in intracellular membrane-bounded organelles and midbody. Exhibits anti-inflammatory effects, impacting pathways associated with positive regulation of membrane permeability, supporting Defa26 function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
1-Hydroxypyridine-2-thione zinc salt, directly activating Defa26 by modulating zinc homeostasis. Enhances expression by influencing zinc-dependent pathways crucial for defense response to other organisms. Regulates intracellular membrane-bounded organelles and midbody, promoting transcriptional activation of Defa26. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Nrf2 activator, directly activating Defa26 via Nrf2-mediated signaling. Enhances expression by modulating antioxidant response elements. Impacts extracellular space, promoting involvement in the defense response to other organisms. Acts as an inducer of phase II detoxification enzymes, influencing cellular defense mechanisms and supporting Defa26 function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Indirect activator of Defa26 through modulation of the JAK/STAT pathway. Enhances expression by influencing signaling cascades involved in the defense response to other organisms. Promotes activation, contributing to role in intracellular membrane-bounded organelles and midbody. Exhibits anti-inflammatory effects, impacting cellular processes associated with positive regulation of membrane permeability. | ||||||
2-Furoic acid | 88-14-2 | sc-230362 sc-230362A | 5 g 100 g | $20.00 $31.00 | ||
Small molecule indirectly activating Defa26 by affecting cell signaling pathways. Enhances expression by influencing pathways associated with defense response to other organisms. Promotes involvement in intracellular membrane-bounded organelles and midbody. Exhibits anti-inflammatory effects, impacting cellular processes associated with positive regulation of membrane permeability and supporting Defa26 function. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
AMPK activator, directly activating Defa26 via AMPK activation. Enhances expression by modulating cellular energy sensing pathways crucial for positive regulation of membrane permeability. Regulates intracellular membrane-bounded organelles and midbody, promoting transcriptional activation of Defa26. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium salt of butyric acid, indirectly activating Defa26. Acts as an HDAC inhibitor, inducing histone acetylation and upregulating defense response to other organisms. Influences chromatin structure, impacting the extracellular space where Defa26 is active. Promotes expression by affecting the epigenetic landscape and contributing to positive regulation of membrane permeability. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Nonsteroidal anti-inflammatory drug indirectly activating Defa26 via COX-2 pathway modulation. Enhances expression by influencing inflammatory responses. Promotes involvement in intracellular membrane-bounded organelles and midbody. Exhibits anti-inflammatory effects, impacting cellular processes associated with positive regulation of membrane permeability and supporting Defa26 function. | ||||||