cryptdin 25 Activators
Defa25, an alpha-defensin 25, is predicted to enable protein homodimerization activity and plays a multifaceted role in various processes, including antimicrobial humoral immune responses, innate immune responses in mucosa, and defense responses to bacteria. Located in the extracellular region, Defa25 is orthologous to human genes DEFA3 and DEFA6, indicating its importance in the intricate network of innate immune defense.
Activation of Defa25 involves a complex interplay of signaling pathways and cellular processes. Chemicals such as retinoic acid, butyrate, and sulforaphane directly or indirectly activate Defa25 by modulating specific pathways. Retinoic acid, for instance, binds to retinoic acid receptors, enhancing Defa25 expression crucial for antimicrobial humoral immune responses and innate immune defense in mucosa. Indirect activators like EGCG and berberine impact AMPK and PI3K/Akt pathways, respectively, enhancing Defa25 expression and supporting its role in extracellular defense against bacteria. These chemicals contribute to the intricate regulatory mechanisms governing Defa25 activation, highlighting the sophisticated nature of innate immune responses and mucosal defense mechanisms orchestrated by this alpha-defensin.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts as a direct activator of Defa25 by binding to retinoic acid receptors (RARs) and modulating transcription. Enhances the expression of Defa25 by influencing the RAR signaling pathway, crucial for antimicrobial humoral immune responses. Regulates the transcriptional activation of Defa25, promoting its involvement in the extracellular space and innate immune responses in mucosa. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Indirect activator of Defa25 by epigenetic modulation. Acts as an HDAC inhibitor, leading to histone acetylation and subsequent upregulation of antimicrobial humoral immune responses. Influences chromatin structure, impacting the extracellular space where Defa25 is located. Promotes the expression of Defa25 by affecting the epigenetic landscape and contributing to innate immune responses in mucosa. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Phytochemical indirectly activating Defa25 via Nrf2-mediated signaling. Enhances the expression of Defa25 by modulating antioxidant response elements. Impacts the extracellular space, promoting the protein's involvement in antimicrobial humoral immune responses. Acts as an inducer of phase II detoxification enzymes, influencing cellular defense mechanisms and supporting Defa25 function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Indirect activator of Defa25 through modulation of the JAK/STAT pathway. Enhances the expression of Defa25 by influencing signaling cascades involved in antimicrobial humoral immune responses. Acts by promoting the activation of Defa25, contributing to its role in the extracellular space and innate immune defense mechanisms. Exhibits anti-inflammatory effects, impacting cellular processes associated with mucosal innate immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate from green tea, an indirect activator of Defa25 via AMPK activation. Modulates cellular energy sensing pathways, leading to increased expression of antimicrobial humoral immune responses. Enhances the involvement of Defa25 in the extracellular space by influencing signaling cascades related to mucosal innate immune responses. Exhibits antioxidant properties, supporting Defa25 function in antimicrobial defense mechanisms. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Alkaloid indirectly activating Defa25 by modulating the PI3K/Akt pathway. Enhances the expression of Defa25 by influencing cellular signaling cascades. Promotes the protein's involvement in antimicrobial humoral immune responses in the extracellular space. Exhibits anti-inflammatory properties, impacting pathways associated with mucosal innate immune responses and supporting Defa25 function in defense against bacteria. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Naturally occurring compound indirectly activating Defa25 via AhR signaling pathway modulation. Enhances the expression of Defa25 by influencing gene expression related to antimicrobial humoral immune responses. Promotes the protein's involvement in the extracellular space, supporting its role in mucosal defense mechanisms against bacteria. Exhibits anti-inflammatory effects, impacting cellular processes associated with innate immune responses in mucosa and contributing to Defa25 function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavonoid indirectly activating Defa25 through Wnt/β-catenin pathway modulation. Enhances the expression of Defa25 by influencing intracellular signaling cascades. Promotes the protein's involvement in antimicrobial humoral immune responses in the extracellular space. Exhibits anti-inflammatory properties, impacting cellular processes associated with mucosal innate immune responses and supporting Defa25 function in defense against bacteria. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Carotenoid pigment indirectly activating Defa25 through PI3K/Akt pathway modulation. Enhances the expression of Defa25 by influencing cellular signaling cascades. Promotes the protein's involvement in antimicrobial humoral immune responses in the extracellular space. Exhibits antioxidant properties, supporting Defa25 function in antimicrobial defense mechanisms. Impacts pathways associated with mucosal innate immune responses. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Nonsteroidal anti-inflammatory drug indirectly activating Defa25 via COX-2 pathway modulation. Enhances the expression of Defa25 by influencing inflammatory responses. Promotes the protein's involvement in antimicrobial humoral immune responses in the extracellular space. Exhibits anti-inflammatory effects, impacting cellular processes associated with mucosal innate immune responses and supporting Defa25 function in defense against bacteria. | ||||||