cryptdin 24 Activators
Defa24, a gene encoding alpha-defensin 24, is predicted to enable protein homodimerization activity and acts upstream of or within the antibacterial humoral response. Located in the extracellular space, Defa24 plays a pivotal role in defending against bacterial threats. Its orthology to human genes, including DEFA3 and DEFA6, underscores its significance in the complex network of innate immune responses.
Activation of Defa24 involves a sophisticated interplay of signaling pathways and cellular processes. Chemicals such as retinoic acid, butyrate, and sulforaphane directly or indirectly activate Defa24 by modulating specific pathways. For instance, retinoic acid binds to retinoic acid receptors, enhancing Defa24 expression crucial for antibacterial humoral responses. Butyrate, an HDAC inhibitor, influences histone acetylation, promoting Defa24 involvement in the extracellular antibacterial defense. Indirect activators like EGCG and berberine impact AMPK and PI3K/Akt pathways, respectively, enhancing Defa24 expression and supporting its role in antibacterial humoral responses. These chemicals contribute to the complex regulatory mechanisms governing Defa24 activation, highlighting the intricate nature of innate immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts as a direct activator of Defa24 by binding to retinoic acid receptors (RARs) and modulating transcription. Enhances the expression of Defa24 by influencing the RAR signaling pathway, crucial for antibacterial humoral responses. Regulates the transcriptional activation of Defa24, promoting its involvement in the extracellular antibacterial response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Indirect activator of Defa24 by epigenetic modulation. Acts as an HDAC inhibitor, leading to histone acetylation and subsequent upregulation of antibacterial humoral responses. Influences chromatin structure, impacting the extracellular space where Defa24 is located. Promotes the expression of Defa24 by affecting the epigenetic landscape and contributing to the antibacterial immune response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Phytochemical indirectly activating Defa24 via Nrf2-mediated signaling. Enhances the expression of Defa24 by modulating antioxidant response elements. Impacts the extracellular space, promoting the protein's involvement in antibacterial humoral responses. Acts as an inducer of phase II detoxification enzymes, influencing cellular defense mechanisms and supporting Defa24 function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Indirect activator of Defa24 through modulation of the JAK/STAT pathway. Enhances the expression of Defa24 by influencing signaling cascades involved in antibacterial humoral responses. Acts by promoting the activation of Defa24, contributing to its role in the extracellular space and antibacterial defense mechanisms. Exhibits anti-inflammatory effects, impacting cellular processes associated with the innate immune response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate from green tea, an indirect activator of Defa24 via AMPK activation. Modulates cellular energy sensing pathways, leading to increased expression of antibacterial humoral responses. Enhances the involvement of Defa24 in the extracellular space by influencing signaling cascades related to the innate immune response. Exhibits antioxidant properties, supporting Defa24 function in antibacterial defense mechanisms. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Alkaloid indirectly activating Defa24 by modulating the PI3K/Akt pathway. Enhances the expression of Defa24 by influencing cellular signaling cascades. Promotes the protein's involvement in antibacterial humoral responses in the extracellular space. Exhibits anti-inflammatory properties, impacting pathways associated with the innate immune response and supporting Defa24 function in antibacterial defense mechanisms. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Naturally occurring compound indirectly activating Defa24 via AhR signaling pathway modulation. Enhances the expression of Defa24 by influencing gene expression related to antibacterial humoral responses. Promotes the protein's involvement in the extracellular space, supporting its role in antibacterial defense mechanisms. Exhibits anti-inflammatory effects, impacting cellular processes associated with the innate immune response and contributing to Defa24 function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavonoid indirectly activating Defa24 through Wnt/β-catenin pathway modulation. Enhances the expression of Defa24 by influencing intracellular signaling cascades. Promotes the protein's involvement in antibacterial humoral responses in the extracellular space. Exhibits anti-inflammatory properties, impacting cellular processes associated with the innate immune response and supporting Defa24 function in antibacterial defense mechanisms. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Carotenoid pigment indirectly activating Defa24 through PI3K/Akt pathway modulation. Enhances the expression of Defa24 by influencing cellular signaling cascades. Promotes the protein's involvement in antibacterial humoral responses in the extracellular space. Exhibits antioxidant properties, supporting Defa24 function in antibacterial defense mechanisms. Impacts pathways associated with the innate immune response. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Nonsteroidal anti-inflammatory drug indirectly activating Defa24 via COX-2 pathway modulation. Enhances the expression of Defa24 by influencing inflammatory responses. Promotes the protein's involvement in antibacterial humoral responses in the extracellular space. Exhibits anti-inflammatory effects, impacting cellular processes associated with the innate immune response and supporting Defa24 function in antibacterial defense mechanisms. | ||||||