Crumbs Inhibitors
Crumbs inhibitors encompass a diverse range of chemical classes, each targeting different proteins or pathways that may indirectly influence Crumbs protein function and localization within the cell. These inhibitors target a variety of cellular mechanisms, such as cytoskeletal dynamics, cell signaling pathways, and protein trafficking, which are all critical for the proper functioning and localization of the Crumbs protein.
Cytoskeletal inhibitors such as Y-27632, NSC 23766, ML141, Blebbistatin, and Cytochalasin D, act on the actin and myosin components of the cytoskeleton, which are vital for cell shape, polarity, and intracellular movement. Changes in the cytoskeleton can affect the positioning and function of Crumbs at the cellular membrane. On the other hand, inhibitors like LY294002, Wortmannin, and XAV-939 target specific signaling pathways, such as PI3K, Wnt/β-catenin, and Notch, which can influence a multitude of cellular events including those that determine cell polarity and membrane protein localization. By altering these pathways, the stability and activity of Crumbs can be indirectly affected. Similarly, Brefeldin A disrupts protein trafficking by affecting the Golgi apparatus, which could lead to changes in the delivery of the Crumbs protein to the cell surface. PD98059 and SB203580, which inhibit MEK and p38 MAPK respectively, can modify the MAPK signaling pathway, potentially leading to alterations in processes related to Crumbs function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that can indirectly affect Crumbs function by altering cytoskeletal dynamics. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
Inhibitor of Rac1, which may influence Crumbs localization through actin cytoskeleton reorganization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that can lead to altered cell signaling pathways affecting Crumbs protein stabilization. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi apparatus function, potentially influencing Crumbs trafficking to the plasma membrane. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that can alter MAPK signaling pathways, indirectly affecting Crumbs-related processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that can modify cellular processes linked with Crumbs signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that can affect signaling pathways and indirectly influence Crumbs stability and localization. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibits Wnt/β-catenin signaling, which can modify cellular processes that interact with Crumbs function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Notch pathway inhibitor that can alter cell fate decisions and potentially affect Crumbs-related polarity establishment. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II, potentially affecting tension and polarity in cells, which could influence Crumbs positioning. | ||||||