Date published: 2026-3-3

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CRSP150_CRSP2 Inhibitors

CRSP150 and CRSP2 inhibitors represent a specific class of chemical compounds that have garnered attention in the field of molecular biology and gene regulation research. CRSP150 and CRSP2, also known as MED23 and MED18, respectively, are subunits of the Mediator complex, a critical molecular assembly that plays a central role in regulating transcription, which is the process by which genetic information is used to synthesize RNA from DNA. The term CRSP150_CRSP2 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activities of these two Mediator subunits. These inhibitors serve as indispensable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with CRSP150 and CRSP2.

CRSP150_CRSP2 inhibitors typically function by interfering with the roles of CRSP150 and CRSP2 within the Mediator complex, which acts as a bridge between transcription factors and RNA polymerase, facilitating the initiation and regulation of gene transcription. This interference can lead to alterations in gene expression profiles, impacting various cellular pathways and processes. Researchers employ CRSP150_CRSP2 inhibitors to gain insights into the physiological roles and molecular interactions of these Mediator subunits within cells, aiming to advance our understanding of the fundamental mechanisms involved in gene regulation. Through the study of CRSP150_CRSP2 inhibitors, scientists seek to unravel the complexities of transcriptional regulation, uncover novel insights into the biology of Mediator complexes, and contribute to our understanding of how cells precisely control gene expression to orchestrate various cellular functions.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide is known to inhibit transcriptional activity, which could lead to the downregulation of CRSP150_CRSP2 expression by affecting its transcription.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Actinomycin D intercalates into DNA, preventing RNA synthesis. This could indirectly inhibit CRSP150_CRSP2 expression at the transcriptional level.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

α-Amanitin is a potent inhibitor of RNA polymerase II, potentially decreasing the transcription of genes including CRSP150_CRSP2.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$43.00
$189.00
$316.00
$663.00
6
(1)

DrB inhibits RNA Polymerase II, possibly reducing CRSP150_CRSP2 mRNA synthesis and hence its expression.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$259.00
41
(3)

A cyclin-dependent kinase inhibitor that could lower transcription levels of many genes, potentially including CRSP150_CRSP2.

ICRF-193

21416-68-2sc-200889
sc-200889A
1 mg
5 mg
$341.00
$927.00
7
(1)

It is a topoisomerase II inhibitor that could indirectly affect transcription and reduce CRSP150_CRSP2 expression.

Leptomycin B

87081-35-4sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$107.00
$416.00
$1248.00
35
(2)

Inhibits nuclear export by binding to exportin 1, which could influence the subcellular localization and stability of CRSP150_CRSP2 mRNA.

Cordycepin

73-03-0sc-203902
10 mg
$101.00
5
(1)

An adenosine analog that can terminate RNA synthesis prematurely and could potentially inhibit CRSP150_CRSP2 expression.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

A BET bromodomain inhibitor, which may indirectly downregulate transcription of certain genes, possibly including CRSP150_CRSP2.

Rocaglamide

84573-16-0sc-203241
sc-203241A
sc-203241B
sc-203241C
sc-203241D
100 µg
1 mg
5 mg
10 mg
25 mg
$275.00
$474.00
$1639.00
$2497.00
$5344.00
4
(1)

It has been shown to inhibit translation and could affect the level of CRSP150_CRSP2 protein by inhibiting its mRNA translation.