CRP Activators
CRP activators represent a diverse group of chemicals that selectively modulate pathways intricately linked to C-reactive protein (CRP) activation. Eicosapentaenoic Acid (EPA), an omega-3 fatty acid, may activate CRP indirectly by mitigating inflammatory pathways, reflecting CRP's role as a biomarker of inflammation. Lipopolysaccharide (LPS), a component of bacterial cell walls, can activate CRP directly by engaging toll-like receptors (TLRs) and triggering downstream signaling cascades.
Tumor Necrosis Factor-alpha (TNF-α), a cytokine, may activate CRP indirectly by initiating inflammatory pathways, while Rosiglitazone, a thiazolidinedione, activates CRP indirectly by influencing inflammation and insulin resistance. Epinephrine, a stress-related hormone, may activate CRP indirectly through stress-related pathways. Toll-like receptor agonists, including Poly(I:C) and Pam3CSK4, activate CRP directly by engaging TLRs. Sodium Salicylate, previously mentioned as an inhibitor, can paradoxically activate CRP indirectly by influencing pro-inflammatory pathways. Niacin (Nicotinic Acid), used to modify lipid profiles, may activate CRP indirectly by modulating lipid metabolism and inflammation-related pathways. Platelet-Activating Factor (PAF) activates CRP indirectly by influencing inflammatory pathways. 15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) activates CRP indirectly by modulating inflammatory and oxidative stress pathways. Ceramide, a sphingolipid, may activate CRP indirectly by influencing pathways related to apoptosis and inflammation. Collectively, these activators provide valuable tools for researchers to explore the intricate regulatory mechanisms governing CRP activity, contributing to a deeper understanding of CRP's multifaceted roles in cellular physiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
Eicosapentaenoic Acid (EPA) is an omega-3 fatty acid found in fish oil. It may activate CRP indirectly by modulating inflammatory pathways, as CRP is a biomarker of inflammation, and EPA has anti-inflammatory properties. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
Lipopolysaccharide (LPS), a component of bacterial cell walls, can potentially activate CRP directly by interacting with toll-like receptors (TLRs) and activating downstream signaling pathways. CRP is known to be induced in response to infections, including those involving bacterial components such as LPS. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, a thiazolidinedione, may activate CRP indirectly by modulating pathways related to inflammation and insulin resistance. CRP levels are associated with metabolic disorders, and thiazolidinediones like rosiglitazone are studied in the research of type 2 diabetes, suggesting a potential link between these compounds and CRP activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, a hormone and neurotransmitter, may activate CRP indirectly by influencing stress-related pathways. CRP levels have been reported to increase in response to stress, and epinephrine is a key mediator of the stress response, suggesting a potential connection between epinephrine and CRP activation. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium Salicylate, previously mentioned as an inhibitor, may also activate CRP indirectly by influencing pro-inflammatory pathways. While NSAIDs like sodium salicylate can inhibit inflammation, paradoxically, they may also trigger the acute-phase response, potentially leading to increased CRP expression. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Niacin, also known as nicotinic acid, may activate CRP indirectly by modulating lipid metabolism and inflammation-related pathways. CRP levels are associated with cardiovascular risk, and niacin is used to modify lipid profiles, suggesting a potential link between niacin and CRP activation. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $128.00 $294.00 | 10 | |
Platelet-Activating Factor (PAF) may activate CRP indirectly by influencing inflammatory pathways. PAF is a pro-inflammatory lipid mediator that can trigger the acute-phase response, potentially leading to increased CRP expression. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $138.00 $540.00 | 5 | |
15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) may activate CRP indirectly by modulating inflammatory and oxidative stress pathways. CRP is associated with inflammation and oxidative stress, and 15d-PGJ2 has anti-inflammatory and antioxidant properties, suggesting a potential role in CRP activation. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $77.00 $316.00 | 12 | |
Ceramide, a sphingolipid, may activate CRP indirectly by modulating pathways related to apoptosis and inflammation. CRP has been linked to apoptosis, and ceramide is involved in various cellular processes, including apoptosis and inflammation, suggesting a potential connection between ceramide and CRP activation. | ||||||