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creatine kinase-B Inhibitors

Creatine kinase-B inhibitors, as categorized here, are a diverse group of chemicals that influence the activity of CK-B indirectly by affecting various cellular processes or pathways related to energy metabolism. These chemicals do not inhibit CK-B directly but modulate its activity through alterations in cellular energy states, redox balance, or by interacting with key functional groups within the enzyme. The primary method by which these chemicals can influence CK-B involves the alteration of cellular energy metabolism. Compounds such as Malonate, Sodium Fluoride, Beta-GPA, Metformin, Dichloroacetate, Sodium Azide, Rotenone, and Oligomycin affect different aspects of energy production and utilization within the cell. By altering pathways such as glycolysis, the Krebs cycle, or oxidative phosphorylation, these compounds can impact the availability of ATP and creatine, which are substrates or products of CK-B. For instance, Malonate inhibits succinate dehydrogenase, leading to changes in the Krebs cycle, which can indirectly affect CK-B activity by altering the cellular energy state.In addition to these, other compounds listed such as 2,4-Dinitrofluorobenzene, Iodoacetamide, Nitrate, and Allopurinol, interact with or influence specific biochemical groups or pathways that can impact CK-B function. For example, 2,4-Dinitrofluorobenzene and Iodoacetamide can modify cysteine residues, which are crucial for CK-B's enzymatic activity. Alterations in the redox state by compounds like Nitrate can also affect CK-B indirectly, as redox changes can influence various metabolic enzymes and pathways. In summary, CK-B inhibitors, as classified here, are compounds that impact the activity of CK-B through indirect mechanisms by modulating cellular energy states, redox balance, or directly interacting with functional groups on the enzyme. Their influence on CK-B is rooted in their ability to alter the cellular environment, particularly in terms of energy availability and metabolism, thereby affecting the functional context in which CK-B operates within the cell. These inhibitors showcase the complex interplay between cellular metabolism and the functional modulation of key metabolic enzymes like CK-B.

Items 1 to 10 of 11 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
BU99006		sc-300307	5 mg	$207.00	3	(0)
BU99006 functions as a potent inhibitor of creatine kinase-b, exhibiting selective binding that disrupts the enzyme's catalytic activity. Its unique molecular structure allows for specific interactions with the enzyme's active site, altering reaction kinetics and inhibiting substrate conversion. The compound's hydrophobic regions enhance its affinity for the enzyme, while its dynamic conformational changes facilitate effective competition with natural substrates, impacting energy metabolism pathways.
1-Fluoro-2,4-dinitrobenzene	70-34-8	sc-213329 sc-213329A	10 ml 25 ml	$126.00 $189.00		(0)
1-Fluoro-2,4-dinitrobenzene reacts with thiol groups in proteins. CK-B has cysteine residues critical for its activity, and modification of these residues could result in enzyme inhibition.
α-Iodoacetamide	144-48-9	sc-203320	25 g	$250.00	1	(1)
Iodoacetamide alkylates cysteine residues. Alkylation of cysteine residues in CK-B could hinder its enzymatic activity.
Sodium Fluoride	7681-49-4	sc-24988A sc-24988 sc-24988B	5 g 100 g 500 g	$39.00 $45.00 $98.00	26	(4)
Sodium Fluoride is an inhibitor of various enzymes, including phosphatases and glycolytic enzymes. By inhibiting these enzymes, sodium fluoride can alter the energy metabolism of the cell, indirectly affecting CK-B activity.
3-Guanidinopropionic acid	353-09-3	sc-254485 sc-254485A	1 g 5 g	$55.00 $193.00		(1)
3-GPA is a creatine analogue that competes with creatine for uptake and can deplete intracellular creatine levels. Reduced creatine levels can indirectly inhibit CK-B activity, as CK-B utilizes creatine as a substrate.
Allopurinol	315-30-0	sc-207272	25 g	$128.00		(0)
Allopurinol is a xanthine oxidase inhibitor. By inhibiting xanthine oxidase, allopurinol can alter purine metabolism, which can indirectly influence CK-B activity due to changes in cellular energy status.
Metformin	657-24-9	sc-507370	10 mg	$77.00	2	(0)
Metformin is an antidiabetic drug that affects glucose metabolism. By altering glucose metabolism, metformin can indirectly affect CK-B activity, as CK-B is involved in energy metabolism.
Sodium dichloroacetate	2156-56-1	sc-203275 sc-203275A	10 g 50 g	$54.00 $205.00	6	(1)
Dichloroacetate stimulates pyruvate dehydrogenase, altering glucose and lactate metabolism. These changes can indirectly affect CK-B activity by altering the cellular energy state.
Sodium azide	26628-22-8	sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A	25 g 250 g 1 kg 2.5 kg 100 g	$42.00 $152.00 $385.00 $845.00 $88.00	8	(2)
Sodium Azide inhibits cytochrome c oxidase in the mitochondrial electron transport chain. Inhibition of this chain can alter ATP production, potentially affecting CK-B activity indirectly due to changes in energy metabolism.
Rotenone	83-79-4	sc-203242 sc-203242A	1 g 5 g	$89.00 $254.00	41	(1)
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting electron transport, rotenone can affect ATP production and cellular energy levels, indirectly impacting CK-B activity.

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creatine kinase-B Inhibitors

BU99006

1-Fluoro-2,4-dinitrobenzene

α-Iodoacetamide

Sodium Fluoride

3-Guanidinopropionic acid

Allopurinol

Metformin

Sodium dichloroacetate

Sodium azide

Rotenone