Molecular structure of BU99006
BU99006
See product citations (3)
Alternate Names:
2-(Imidazolin-2-yl)-5-isothiocyanatobenzofuran
Application:
BU99006 is an irreversible I2 imidazoline binding site ligand
Molecular Weight:
243.28
Molecular Formula:
C12H9N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BU99006 is an irreversible ligand, which binds to subgroup I2 imidazoline binding proteins. Studies indicate that BU99006 inhibits creatine kinase-B (brain creatine kinase) by covalently binding to Cys283 of the enzymes active site. In addition, BU99006 may act to irreversibly inhibit [(3)H]2BFI binding to the active site of I2 imidazoline. Studies suggest that I2 imidazoline compounds can partially or fully agonize D2DR (D2-dopamine receptors) with a strength similar to dopamine. BU99006 is a versatile compound that can be ideal in monitoring the function of D2DR and ligand binding in I2 imidazoline compounds.
BU99006 References
- Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. | Coates, PA., et al. 2000. Bioorg Med Chem Lett. 10: 605-7. PMID: 10741563
- 5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) an irreversible imidazoline(2) binding site ligand: in vitro and in vivo characterisation in rat brain. | Tyacke, RJ., et al. 2002. Neuropharmacology. 43: 75-83. PMID: 12213261
- Relationship between imidazoline(2) sites and monoamine oxidase. | Paterson, LM., et al. 2003. Ann N Y Acad Sci. 1009: 353-6. PMID: 15028610
- Initial evaluation of novel selective ligands for imidazoline(2) receptors in rat whole brain. | Tyacke, RJ., et al. 2003. Ann N Y Acad Sci. 1009: 357-60. PMID: 15028611
- Identification of an I(2) binding protein from rabbit brain. | Kimura, A., et al. 2003. Ann N Y Acad Sci. 1009: 364-6. PMID: 15028613
- Imidazoline binding sites and their ligands: an overview of the different chemical structures. | Dardonville, C. and Rozas, I. 2004. Med Res Rev. 24: 639-61. PMID: 15224384
- In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites. | Paterson, LM., et al. 2007. Neuropharmacology. 52: 395-404. PMID: 17045310
- Modulation of stress by imidazoline binding sites: implications for psychiatric disorders. | Smith, KL., et al. 2009. Stress. 12: 97-114. PMID: 19006007
- Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site. | Kimura, A., et al. 2009. Brain Res. 1279: 21-8. PMID: 19410564
- Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI. | Giorgioni, G., et al. 2010. Bioorg Med Chem. 18: 7085-91. PMID: 20801048
- Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats. | Qiu, Y., et al. 2014. Behav Pharmacol. 25: 130-6. PMID: 24518265
- Dysregulation of IRAS/nischarin and other potential I1-imidazoline receptors in major depression postmortem brain: Downregulation of basal contents by antidepressant drug treatments. | Keller, B. and García-Sevilla, JA. 2017. J Affect Disord. 208: 646-652. PMID: 27836117
- Effects of I2-imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I1-IR and μ-opioid receptor proteins and modulation of associated signalling pathways. | Keller, B. and García-Sevilla, JA. 2017. Neurochem Int. 108: 169-176. PMID: 28342965
- Morphine Binds Creatine Kinase B and Inhibits Its Activity. | Weinsanto, I., et al. 2018. Front Cell Neurosci. 12: 464. PMID: 30559651
- A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs. | Giovinazzo, H., et al. 2019. Oncotarget. 10: 3040-3050. PMID: 31105884
Inhibitor of:
creatine kinase-B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BU99006, 5 mg | sc-300307 | 5 mg | $240.00 |