CRB2 Inhibitors
Chemical inhibitors of CRB2 engage in various strategies to hinder its function within cellular signaling pathways. Staurosporine, by its nature as a broad-spectrum kinase inhibitor, can disrupt the phosphorylation processes crucial for CRB2's signaling roles, particularly those associated with cell polarity and junction assembly. LY294002 and Wortmannin, as PI3K inhibitors, can blunt the PI3K/Akt pathway's input into CRB2-regulated processes like cell survival and polarity, due to their capacity to thwart kinase activity upstream of these CRB2-mediated events. Y-27632 targets Rho-associated protein kinase (ROCK), potentially leading to cytoskeletal disorganization, which is intimately tied to CRB2's role in maintaining cell polarity. Similarly, PD98059 and U0126, both inhibitors of the MEK/ERK pathway, can dampen the MAPK signaling cascade, which is essential for CRB2's involvement in cell differentiation and polarity, by preventing the activation of kinases crucial for these processes.
Complementing these, SB203580 and SP600125, targeting p38 MAP kinase and JNK respectively, can interfere with stress response and apoptosis regulation, processes where CRB2 plays a significant role. The Src family kinases, targeted by PP2, are involved in pathways regulating cell migration and polarization, where CRB2 is also a key player. The inhibition by PP2 can therefore impact CRB2's function in these dynamic cellular events. Lestaurtinib, a tyrosine kinase inhibitor, can suppress the activity of kinases that partake in cell adhesion and migration, processes where CRB2 has functional importance. Rapamycin's inhibition of mTOR, a pivotal regulator of cell growth and proliferation, can likewise impinge upon CRB2-involved signaling related to cell size and polarity. Lastly, Gefitinib's role as an EGFR inhibitor can disrupt the EGFR signaling cascades that are central to the CRB2's regulatory functions in epithelial cell polarity and proliferation, delineating a direct avenue by which CRB2's activity can be inhibited.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent kinase inhibitor that can inhibit a broad range of kinases. Given that CRB2 is involved in cellular signaling pathways that are regulated by phosphorylation events, staurosporine could inhibit CRB2 function by altering the activity of kinases that are required for CRB2's role in those pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). Since CRB2 is known to interact with the PI3K/Akt pathway, inhibition of PI3K by LY294002 can lead to a decrease in Akt phosphorylation and activity, thereby potentially inhibiting CRB2 function in cell polarity and tight junction assembly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). CRB2's function in maintaining apical-basal polarity is influenced by the actin cytoskeleton, which is regulated by ROCK. Inhibition of ROCK may therefore disrupt the cytoskeletal organization and subsequently CRB2's role in cell polarity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), a part of the MAPK/ERK pathway. CRB2, through its interaction with the scaffolding protein MUPP1, is connected with MAPK signaling. Inhibition of MEK could therefore attenuate the pathway's influence on CRB2 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. CRB2 is implicated in stress response pathways modulated by p38 MAPK. By inhibiting p38 MAPK, SB203580 could impair stress-induced signaling events that affect CRB2 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK pathway is involved in the regulation of cell polarity and apoptosis, processes that CRB2 is known to affect. Inhibition by SP600125 could disrupt JNK-mediated CRB2 functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. By inhibiting PI3K, Wortmannin can disrupt the PI3K/Akt signaling pathway, which is critical for CRB2-mediated regulation of cellular processes such as cell survival and polarity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. CRB2 is part of cellular pathways that rely on Src signaling for processes like cell migration and polarization, and PP2 can inhibit these Src-dependent pathways, affecting CRB2 function. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $275.00 $326.00 $612.00 | 3 | |
Lestaurtinib is a tyrosine kinase inhibitor that may affect multiple kinases involved in signaling pathways related to CRB2 function, such as cell adhesion and migration. Inhibition of these kinases could impede CRB2's functional role in these processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR (mammalian target of rapamycin), which is crucial for cell growth and proliferation. mTOR signaling intersects with pathways involving CRB2, and its inhibition with rapamycin could disrupt CRB2-mediated signaling involved in cell size and polarity. | ||||||