Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A binds to the Qi site of Complex III in the mitochondrial electron transport chain, where COX6b2 is a component of Complex IV. This binding inhibits the transfer of electrons from cytochrome b to cytochrome c1, which creates a back pressure of electrons that can indirectly inhibit the activity of Complex IV by reducing its electron substrate availability. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits Complex IV directly by binding to the heme group in cytochrome c oxidase, thereby blocking electron transfer from cytochrome c to oxygen, effectively inhibiting the function of COX6b2 within the complex. | ||||||
Azoxystrobin | 131860-33-8 | sc-364349A sc-364349 sc-364349B sc-364349C | 25 mg 100 mg 500 mg 1 g | $50.00 $152.00 $458.00 $848.00 | 1 | |
Azoxystrobin acts as an inhibitor of Complex III by binding to the Qo site, however, by inhibiting Complex III, it can lead to reduced ubiquinol availability for Complex IV, thus indirectly inhibiting the function of COX6b2. | ||||||
Myxothiazol | 76706-55-3 | sc-507550 | 1 mg | $145.00 | ||
Myxothiazol is an inhibitor of Complex III, binding at the Qi site and preventing electron transfer to cytochrome c. As a part of the downstream effect, this can inhibit the activity of COX6b2 in Complex IV by limiting its substrate, cytochrome c. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Although Oligomycin is a known inhibitor of ATP synthase (Complex V), its action leads to a build-up of protons within the mitochondrial matrix, which can decrease the proton gradient, indirectly affecting the activity of COX6b2 in Complex IV due to decreased efficiency in the electron transport chain. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase (Complex II), which can reduce electron flow through the electron transport chain. Reduced electron availability at Complex IV can functionally inhibit COX6b2 as part of the complex's activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone binds to and inhibits Complex I of the mitochondrial electron transport chain. This inhibition can cause a reduction in the electron flow towards downstream complexes, including Complex IV, indirectly inhibiting the functional activity of COX6b2. |