Date published: 2025-10-19

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COX6b2 Inhibitors

Chemical inhibitors of COX6b2 function primarily by disrupting the mitochondrial electron transport chain (ETC), where this protein operates as a component of cytochrome c oxidase, also known as Complex IV. Antimycin A, for instance, targets Complex III by binding to the Qi site, creating a backup of electrons that indirectly hinders the electron substrate availability for Complex IV and thus inhibits the activity of COX6b2 within it. Similarly, Sodium azide and Hydrogen sulfide exert their inhibitory effects directly on Complex IV; Sodium azide does this by binding to the heme group and blocking electron transfer, while Hydrogen sulfide binds to both the heme moiety and copper centers in the ETC, preventing COX6b2 from effectively participating in cellular respiration. Further inhibitory actions are seen with Carbon monoxide and Potassium cyanide, which compete with oxygen and bind with high affinity to the heme centers of Complex IV, obstructing electron transfer and the corresponding enzymatic activity of COX6b2. Azoxystrobin, although primarily inhibiting Complex III, indirectly impedes COX6b2 function by reducing the ubiquinol pool necessary for Complex IV's activity. Myxothiazol and Stigmatellin, also targeting Complex III, decrease the flow of electrons to cytochrome c, thereby reducing the electron supply to COX6b2 within Complex IV. Cyanide functions similarly to Potassium cyanide, binding to the ferric ion at the heme a3-CuB center, effectively inhibiting the electron transport and the function of COX6b2. Nonetheless, there are inhibitors like Oligomycin that target ATP synthase (Complex V) but still manage to indirectly affect COX6b2 by causing a proton gradient reduction and thus decreasing the efficiency of the entire ETC, which includes the complex that COX6b2 is a part of. Carboxin and Rotenone target other complexes within the ETC (Complex II and I, respectively), but both lead to a decrease in electron flow towards Complex IV, which is essential for COX6b2 activity, thereby functionally inhibiting this protein's role in cellular energy production.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$54.00
$62.00
$1642.00
$4600.00
51
(1)

Antimycin A binds to the Qi site of Complex III in the mitochondrial electron transport chain, where COX6b2 is a component of Complex IV. This binding inhibits the transfer of electrons from cytochrome b to cytochrome c1, which creates a back pressure of electrons that can indirectly inhibit the activity of Complex IV by reducing its electron substrate availability.

Sodium azide

26628-22-8sc-208393
sc-208393B
sc-208393C
sc-208393D
sc-208393A
25 g
250 g
1 kg
2.5 kg
100 g
$42.00
$152.00
$385.00
$845.00
$88.00
8
(2)

Sodium azide inhibits Complex IV directly by binding to the heme group in cytochrome c oxidase, thereby blocking electron transfer from cytochrome c to oxygen, effectively inhibiting the function of COX6b2 within the complex.

Azoxystrobin

131860-33-8sc-364349A
sc-364349
sc-364349B
sc-364349C
25 mg
100 mg
500 mg
1 g
$50.00
$152.00
$458.00
$848.00
1
(0)

Azoxystrobin acts as an inhibitor of Complex III by binding to the Qo site, however, by inhibiting Complex III, it can lead to reduced ubiquinol availability for Complex IV, thus indirectly inhibiting the function of COX6b2.

Myxothiazol

76706-55-3sc-507550
1 mg
$145.00
(0)

Myxothiazol is an inhibitor of Complex III, binding at the Qi site and preventing electron transfer to cytochrome c. As a part of the downstream effect, this can inhibit the activity of COX6b2 in Complex IV by limiting its substrate, cytochrome c.

Oligomycin

1404-19-9sc-203342
sc-203342C
10 mg
1 g
$146.00
$12250.00
18
(2)

Although Oligomycin is a known inhibitor of ATP synthase (Complex V), its action leads to a build-up of protons within the mitochondrial matrix, which can decrease the proton gradient, indirectly affecting the activity of COX6b2 in Complex IV due to decreased efficiency in the electron transport chain.

Carboxine

5234-68-4sc-234286
250 mg
$21.00
1
(1)

Carboxin inhibits succinate dehydrogenase (Complex II), which can reduce electron flow through the electron transport chain. Reduced electron availability at Complex IV can functionally inhibit COX6b2 as part of the complex's activity.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$254.00
41
(1)

Rotenone binds to and inhibits Complex I of the mitochondrial electron transport chain. This inhibition can cause a reduction in the electron flow towards downstream complexes, including Complex IV, indirectly inhibiting the functional activity of COX6b2.