COX18 Activators
COX18 Activators are chemical compounds that influence various biochemical pathways and processes to enhance the assembly and activity of cytochrome c oxidase, for which COX18 is essential. Retinoic acid, for instance, directly modulates the gene expression of mitochondrial components, thereby facilitating the proper functional activity of COX18. The presence of sufficient copper ions provided by Copper(II) sulfate is critical for COX18's activity, ensuring the cytochrome c oxidase complex is adequately assembled. Compounds like Bezafibrate and Resveratrol indirectly support COX18 activity by promoting mitochondrial biogenesis through the activation of PPARs and SIRT1 respectively, leading to an increase in the number of mitochondria capable of supporting cytochrome c oxidase assembly. Similarly, N,N-Dimethylglycine, by providing substrates for one-carbon metabolism, and Nicotinamide adenine dinucleotide (NAD+), by enhancing redox reactions, contribute to a healthy mitochondrial environment where COX18 operates.
Furthermore, the functional activity of COX18 is indirectly supported by compounds that assist in maintaining mitochondrial health and optimizing the conditions for the assembly of the cytochrome c oxidase complex. Alpha-lipoic acid and Coenzyme Q10 play key roles in mitochondrial bioenergetics, which can benefitthe actions of COX18. Spermidine, by inducing autophagy, may lead to the removal of dysfunctional mitochondria, increasing the efficiency of those that remain. Pyrroloquinoline quinone (PQQ) supports mitochondrial biogenesis, potentially enhancing COX18 function by increasing the overall capacity for cytochrome c oxidase assembly. Methylene blue assists in the mitochondrial electron transport chain, optimizing the conditions for COX18's role. Finally, Sulforaphane activates the Nrf2 pathway, which is known for upregulating the expression of protective antioxidant proteins, thus maintaining mitochondrial integrity and indirectly supporting the functional activity of COX18 in cytochrome c oxidase assembly. Together, these activators contribute to maintaining a cellular environment that enhances the functionality of COX18, ensuring the efficient assembly and activity of the cytochrome c oxidase complex.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences the electron transport chain in which COX18 is involved. It modulates gene expression for various components of the mitochondrial respiratory chain, thereby enhancing the assembly and activity of cytochrome c oxidase, the complex where COX18 functions. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate provides copper, a cofactor required for the functional activity of COX18, which is involved in the assembly of cytochrome c oxidase. An adequate copper supply can lead to the proper functioning of COX18. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate activates peroxisome proliferator-activated receptors (PPARs) which can enhance the expression of genes involved in mitochondrial function and biogenesis, indirectly supporting the activity of COX18 in cytochrome c oxidase assembly. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme in redox reactions and enhances mitochondrial function, which may have a positive impact on the COX18-mediated assembly of cytochrome c oxidase by supporting the overall mitochondrial health. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ has been shown to support mitochondrial biogenesis and function, which could indirectly enhance the activity of COX18 by increasing the number of properly assembled cytochrome c oxidase complexes. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy and can lead to the removal of dysfunctional mitochondria, potentially increasing the overall efficiency of mitochondria where COX18 is active, thus indirectly enhancing its functional activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid is involved in mitochondrial bioenergetics and can enhance the activity of mitochondrial enzymes, potentially supporting the functional activity of COX18 in the assembly of cytochrome c oxidase. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is a component of the electron transport chain and can support mitochondrial function, indirectly enhancing the activity of COX18 by maintaining an optimal environment for cytochrome c oxidase assembly. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene blue facilitates the transfer of electrons in the electron transport chain, potentially supporting the activity of COX18 by ensuring efficient electron flow through cytochrome c oxidase. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to stimulate mitochondrial biogenesis via the activation of SIRT1, which can indirectly enhance the activity of COX18 by increasing the number of mitochondria with properly assembled cytochrome c oxidase. | ||||||