Cox-2 Inhibitors
Items 11 to 20 of 107 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen functions as a COX-2 inhibitor by engaging in reversible interactions with the enzyme's active site, primarily through the formation of disulfide bonds with cysteine residues. This mechanism alters the enzyme's conformation, impacting its catalytic activity. The compound's unique redox properties enable it to modulate oxidative stress pathways, while its lipophilic nature promotes effective membrane permeability, influencing its distribution and reactivity in cellular environments. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin acts as a COX-2 inhibitor by selectively binding to the enzyme's active site, where it forms hydrogen bonds and hydrophobic interactions with key amino acid residues. This binding stabilizes a conformation that reduces enzyme activity, thereby modulating inflammatory pathways. Its unique structural features, including a bulky aromatic ring, enhance its affinity for the enzyme, while its acidic properties facilitate interactions with biological macromolecules, influencing its reactivity and solubility. | ||||||
Sedanolide | 6415-59-4 | sc-205972 | 100 mg | $151.00 | ||
Sedanolide exhibits its role as a COX-2 inhibitor through a unique mechanism involving the formation of a stable complex with the enzyme. Its distinct cyclic structure allows for specific π-π stacking interactions with aromatic residues, enhancing binding affinity. Additionally, the presence of polar functional groups facilitates dipole-dipole interactions, influencing the enzyme's conformation and activity. This intricate interplay of molecular forces contributes to its selective inhibition profile. | ||||||
Xanthorrhizol | 30199-26-9 | sc-202855 | 1 mg | $194.00 | 1 | |
Xanthorrhizol acts as a COX-2 inhibitor by engaging in specific hydrogen bonding and hydrophobic interactions with the enzyme's active site. Its unique structural features, including a flexible carbon skeleton, allow for conformational adaptability, enhancing its binding efficiency. The compound's ability to modulate enzyme dynamics through allosteric effects further distinguishes its inhibitory action, promoting a nuanced regulation of inflammatory pathways. This multifaceted interaction profile underscores its selective engagement with COX-2. | ||||||
Zaltoprofen | 74711-43-6 | sc-213173 sc-213173A | 10 mg 100 mg | $170.00 $370.00 | 1 | |
Zaltoprofen functions as a COX-2 inhibitor through its distinctive ability to form stable complexes with the enzyme, primarily via π-π stacking and van der Waals forces. Its unique molecular architecture, characterized by a rigid core and functional groups, facilitates precise orientation within the active site. This specificity enhances its kinetic profile, allowing for rapid binding and dissociation, which fine-tunes the modulation of inflammatory mediators. The compound's selective affinity underscores its role in influencing enzymatic activity. | ||||||
NS-398 | 123653-11-2 | sc-200604 sc-200604A | 5 mg 25 mg | $84.00 $332.00 | 9 | |
NS-398 acts as a selective COX-2 inhibitor, distinguished by its unique binding interactions that involve hydrogen bonding and hydrophobic contacts. Its structural features promote a favorable fit within the enzyme's active site, enhancing selectivity over COX-1. The compound exhibits a notable influence on the enzyme's conformational dynamics, which alters the reaction kinetics and modulates the production of prostaglandins. This specificity is crucial for its role in regulating inflammatory pathways. | ||||||
Carprofen | 53716-49-7 | sc-205621 sc-205621A | 1 g 5 g | $80.00 $361.00 | ||
Carprofen functions as a selective COX-2 inhibitor, characterized by its ability to stabilize the enzyme's active site through specific hydrophobic interactions and steric hindrance. This selectivity is further enhanced by its unique molecular conformation, which restricts access to the COX-1 pathway. The compound's kinetic profile reveals a slower dissociation rate from COX-2, allowing for prolonged modulation of inflammatory mediators while minimizing off-target effects. | ||||||
Nabumetone | 42924-53-8 | sc-204813 sc-204813A | 5 g 25 g | $196.00 $587.00 | 3 | |
Nabumetone is a prodrug that converts to an active COX-2 inhibitor in the body. It reduces inflammation and pain by blocking COX-2 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin exhibits selective inhibition of COX-2 through its unique ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This interaction alters the enzyme's conformation, effectively blocking substrate access. Additionally, curcumin's polyphenolic structure enhances its reactivity, allowing it to modulate signaling pathways involved in inflammation. Its dynamic molecular behavior contributes to a favorable kinetic profile, promoting sustained inhibition of COX-2 activity. | ||||||
Robenacoxib | 220991-32-2 | sc-391707 | 100 mg | $265.00 | ||
Robenacoxib selectively targets COX-2 by stabilizing a unique binding conformation that disrupts the enzyme's catalytic activity. Its structural features facilitate specific hydrophobic interactions with the enzyme's active site, enhancing binding affinity. The compound's kinetic properties allow for rapid association and prolonged dissociation, optimizing its inhibitory effects. Furthermore, Robenacoxib's distinct molecular architecture contributes to its ability to modulate downstream inflammatory pathways effectively. | ||||||