Nabumetone (CAS 42924-53-8)
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Nabumetone is a compound extensively studied in the field of organic chemistry, particularly for its role in the modulation of enzyme activity. It is used in research to understand the interaction between small molecules and enzymes that are involved in the production of various chemical mediators. Nabumetone serves as a useful tool for probing the structure-activity relationships of molecules within this class and their effect on enzyme kinetics. Studies involving nabumetone have provided insights into the design of compounds with specific enzyme modulating properties. Furthermore, it is utilized in the examination of the stability and reactivity of the ketone functional group under physiological conditions. Research on nabumetone also contributes to the understanding of how such compounds can influence the production and activity of signaling molecules within cells.
Nabumetone (CAS 42924-53-8) References
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- Low direct cytotoxicity of nabumetone on gastric mucosal cells. | Arai, Y., et al. 2005. Dig Dis Sci. 50: 1641-6. PMID: 16133963
- The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function. | Jeremy, JY., et al. 1990. Br J Rheumatol. 29: 116-9. PMID: 2108782
- Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats. | Khan, SA. and McLean, MK. 2012. Vet Clin North Am Small Anim Pract. 42: 289-306, vi-vii. PMID: 22381180
- Effects of nabumetone and dipyrone on experimentally induced gastric ulcers in rats. | Yıldırım, E., et al. 2013. Inflammation. 36: 476-81. PMID: 23129452
- Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites. | Nobilis, M., et al. 2013. J Pharm Biomed Anal. 80: 164-72. PMID: 23584048
- Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. | Matsumoto, K., et al. 2015. Eur J Drug Metab Pharmacokinet. 40: 127-35. PMID: 24659525
- Preparation, characterization and in vitro cytotoxicity of Fenofibrate and Nabumetone loaded solid lipid nanoparticles. | Kumar, R., et al. 2020. Mater Sci Eng C Mater Biol Appl. 106: 110184. PMID: 31753394
- A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. | Matsumoto, K., et al. 2020. Xenobiotica. 50: 783-792. PMID: 31855101
- Gel Formulation of Nabumetone and a Newly Synthesized Analog: Microemulsion as a Photoprotective Topical Delivery System. | Grande, F., et al. 2020. Pharmaceutics. 12: PMID: 32380748
- Design of a pseudo stir bar sorptive extraction using graphenized pencil lead as the base of the molecularly imprinted polymer for extraction of nabumetone. | Afsharipour, R., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 238: 118427. PMID: 32388234
- Presence or absence of microbiome modulates the response of mice organism to administered drug nabumetone. | Jourová, L., et al. 2020. Physiol Res. 69: S583-S594. PMID: 33646003
- Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line. | Qureshi, S., et al. 2021. Toxicol Appl Pharmacol. 420: 115516. PMID: 33798594
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nabumetone, 5 g | sc-204813 | 5 g | $196.00 | |||
Nabumetone, 25 g | sc-204813A | 25 g | $587.00 |