Molecular structure of NS-398, CAS Number: 123653-11-2
NS-398 (CAS 123653-11-2)
See product citations (9)
Alternate Names:
N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
Application:
NS-398 is a selective Cox-2 inhibitor neuroprotective agent
CAS Number:
123653-11-2
Purity:
≥98%
Molecular Weight:
314.35
Molecular Formula:
C13H18N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NS-398 is a compound utilized in biochemical research for its inhibitory action on the enzyme cyclooxygenase-2 (COX-2). This specificity makes NS-398 a useful tool for scientists studying the enzyme′s role in the synthesis of prostaglandins, which are lipid compounds involved in various cellular processes. By selectively inhibiting COX-2, NS-398 allows for a deeper understanding of the distinct physiological and pathophysiological roles of COX-2-derived prostaglandins, separate from those produced by COX-1. Additionally, NS-398 aids in the exploration of inflammation mechanisms, given the involvement of COX-2 in the inflammatory response. This research contributes to a broader comprehension of enzyme functions in cellular signaling and regulation.
NS-398 (CAS 123653-11-2) References
- Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. | Araki, E., et al. 2001. Stroke. 32: 2370-5. PMID: 11588328
- Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity. | Thomas, DM. and Kuhn, DM. 2005. J Pharmacol Exp Ther. 313: 870-6. PMID: 15718289
- Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by curcumin and COX-2 inhibitor NS-398. | Fernández-Martínez, AB., et al. 2009. Peptides. 30: 2357-64. PMID: 19772879
- A cyclooxygase-2 inhibitor NS-398-enhanced apoptosis of esophageal carcinoma cell EC9706 by adjusting expression of survivin and caspase-3. | Li, S., et al. 2011. Cancer Invest. 29: 102-6. PMID: 21329005
- Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation. | Banu, NA., et al. 2011. Cell Commun Adhes. 18: 1-8. PMID: 21679035
- Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection. | Lee, SM., et al. 2011. Influenza Other Respir Viruses. 5: 230-2. PMID: 21761591
- The structure of NS-398 bound to cyclooxygenase-2. | Vecchio, AJ. and Malkowski, MG. 2011. J Struct Biol. 176: 254-8. PMID: 21843643
- The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. | Sugiyama, T., et al. 2013. Osteoporos Int. 24: 383-8. PMID: 22349912
- Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats. | Tunctan, B., et al. 2010. Basic Clin Pharmacol Toxicol. 107: 877-82. PMID: 22545970
- Effects of COX-2 inhibitor NS-398 on IL-10 expression in rat fungal keratitis. | Li, N., et al. 2011. Int J Ophthalmol. 4: 165-9. PMID: 22553634
- NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite. | Tunctan, B., et al. 2013. Prostaglandins Other Lipid Mediat. 104-105: 93-108. PMID: 22975359
- Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. | Trandafir, CC., et al. 2015. Neuroscience. 284: 601-610. PMID: 25453777
- Retraction Note to: Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. | . 2015. Tumour Biol. 36: 7297. PMID: 26281984
- COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. | Kim, J. and Shim, M. 2016. Mol Carcinog. 55: 2156-2167. PMID: 26756900
- The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis. | Zhang, R., et al. 2016. PLoS One. 11: e0146808. PMID: 26760305
Inhibitor of:
AMZ2, Cox, Cox-2, CUZD1, DPP3, EP2, LOC100041263, LOC285095, LOC728414, LOC728478, LYPD6B, MUDENG, PGE Synthase, PGI2 synthase, PGT, SLC26A3, and Ym1.Activator of:
C11orf74, and Nap-22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NS-398, 5 mg | sc-200604 | 5 mg | $84.00 | |||
NS-398, 25 mg | sc-200604A | 25 mg | $332.00 |