Date published: 2025-11-28

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COTE1 Activators

COTE1 Activators constitute a specialized category of chemical compounds or molecules that have garnered attention within the field of molecular biology and cellular research. These activators are designed or discovered with the specific aim of modulating the activity of the COTE1 gene. COTE1, or Coatomer Subunit Epsilon 1, is a protein-coding gene found in humans and other organisms. It encodes a subunit of the coatomer protein complex, which plays a pivotal role in intracellular transport and vesicle trafficking.

The study of COTE1 activators is intriguing because it provides researchers with a means to explore the precise role of the COTE1 gene in cellular physiology and molecular mechanisms related to vesicular trafficking and cargo transport within cells. Activation of COTE1 can offer valuable insights into its potential involvement in processes such as the formation of transport vesicles, the sorting of proteins, and the regulation of intracellular membrane dynamics. By manipulating the activity of COTE1 through these activators, scientists aim to gain a deeper understanding of the complex molecular pathways and cellular functions that rely on the gene product, thereby contributing to the broader knowledge of intracellular transport and protein trafficking. Consequently, COTE1 activators serve as valuable tools for researchers dedicated to unraveling the intricate molecular mechanisms that govern cellular biology, particularly within the context of intracellular vesicle transport and protein sorting.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C, potentially enhancing endocytosis and the activity of proteins involved in this process.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$87.00
44
(2)

Dynasore is a GTPase inhibitor that can disrupt dynamin-mediated endocytosis, which may indirectly affect associated protein regulators.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$60.00
$108.00
21
(1)

Chlorpromazine interferes with clathrin-mediated endocytosis, which could modulate proteins involved in this pathway.

Methyl-β-cyclodextrin

128446-36-6sc-215379A
sc-215379
sc-215379C
sc-215379B
100 mg
1 g
10 g
5 g
$25.00
$65.00
$170.00
$110.00
19
(1)

Methyl-β-cyclodextrin extracts cholesterol from membranes, potentially affecting membrane dynamics and protein interactions.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein inhibits tyrosine kinases, which could impact signaling pathways regulating endocytosis-associated proteins.

Nystatin

1400-61-9sc-212431
sc-212431A
sc-212431B
sc-212431C
5 MU
25 MU
250 MU
5000 MU
$50.00
$126.00
$246.00
$3500.00
7
(1)

Nystatin perturbs membrane cholesterol, affecting membrane trafficking and potentially the function of trafficking proteins.

Dansylcadaverine

10121-91-2sc-214851
sc-214851A
sc-214851B
100 mg
250 mg
1 g
$51.00
$87.00
$235.00
4
(1)

Monodansylcadaverine is known to inhibit transglutaminase and may affect endocytosis by altering protein interactions.

Filipin III

480-49-9sc-205323
sc-205323A
500 µg
1 mg
$116.00
$145.00
26
(2)

Filipin III binds to cholesterol, disrupting lipid rafts and potentially influencing proteins involved in endosomal trafficking.

Amiloride • HCl

2016-88-8sc-3578
sc-3578A
25 mg
100 mg
$22.00
$56.00
6
(2)

Amiloride modulates Na+/H+ exchange, which might indirectly affect endosomal pH and the function of pH-sensitive proteins.

Pitstop 2

1419320-73-2sc-507418
10 mg
$360.00
(0)

Pitstop 2 is a clathrin inhibitor that may influence the endocytosis process and associated regulatory proteins.