COTE1 Activators constitute a specialized category of chemical compounds or molecules that have garnered attention within the field of molecular biology and cellular research. These activators are designed or discovered with the specific aim of modulating the activity of the COTE1 gene. COTE1, or Coatomer Subunit Epsilon 1, is a protein-coding gene found in humans and other organisms. It encodes a subunit of the coatomer protein complex, which plays a pivotal role in intracellular transport and vesicle trafficking.
The study of COTE1 activators is intriguing because it provides researchers with a means to explore the precise role of the COTE1 gene in cellular physiology and molecular mechanisms related to vesicular trafficking and cargo transport within cells. Activation of COTE1 can offer valuable insights into its potential involvement in processes such as the formation of transport vesicles, the sorting of proteins, and the regulation of intracellular membrane dynamics. By manipulating the activity of COTE1 through these activators, scientists aim to gain a deeper understanding of the complex molecular pathways and cellular functions that rely on the gene product, thereby contributing to the broader knowledge of intracellular transport and protein trafficking. Consequently, COTE1 activators serve as valuable tools for researchers dedicated to unraveling the intricate molecular mechanisms that govern cellular biology, particularly within the context of intracellular vesicle transport and protein sorting.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, potentially enhancing endocytosis and the activity of proteins involved in this process. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor that can disrupt dynamin-mediated endocytosis, which may indirectly affect associated protein regulators. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine interferes with clathrin-mediated endocytosis, which could modulate proteins involved in this pathway. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Methyl-β-cyclodextrin extracts cholesterol from membranes, potentially affecting membrane dynamics and protein interactions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases, which could impact signaling pathways regulating endocytosis-associated proteins. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin perturbs membrane cholesterol, affecting membrane trafficking and potentially the function of trafficking proteins. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $51.00 $87.00 $235.00 | 4 | |
Monodansylcadaverine is known to inhibit transglutaminase and may affect endocytosis by altering protein interactions. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin III binds to cholesterol, disrupting lipid rafts and potentially influencing proteins involved in endosomal trafficking. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride modulates Na+/H+ exchange, which might indirectly affect endosomal pH and the function of pH-sensitive proteins. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is a clathrin inhibitor that may influence the endocytosis process and associated regulatory proteins. | ||||||