Cortisol Inhibitors
Cortisol inhibitors belong to a distinct chemical class of compounds that specifically target and modulate the activity of cortisol, a vital steroid hormone produced by the adrenal glands. These inhibitors are designed to interfere with the biochemical processes involved in the synthesis or function of cortisol within the body. Cortisol is an essential hormone that plays a crucial role in various physiological processes, including metabolism, immune response, stress regulation, and the maintenance of blood pressure.
Cortisol inhibitors work by selectively inhibiting enzymes or receptors that are involved in the production or signaling of cortisol, thereby altering the hormone's overall levels or activity in the body. By targeting cortisol, these inhibitors can elicit various biological effects, which can be significant for certain contexts or conditions where the regulation of cortisol levels is of interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Mifepristone (CAS 84371-65-3) is a potent cortisol receptor antagonist that functions by inhibiting the binding of cortisol to its glucocorticoid receptor. This inhibition disrupts the normal signaling pathways associated with cortisol′s role in regulating metabolic and stress responses, making mifepristone useful in studying cortisol′s biological functions and its effects on various signaling pathways in scientific research. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $41.00 $143.00 $530.00 $2020.00 | 2 | |
Aminoglutethimide (CAS 125-84-8) is a research chemical known for its role as an inhibitor of cortisol synthesis. It functions by blocking the conversion of cholesterol to pregnenolone, a key step in the biosynthesis of cortisol. This inhibition disrupts the steroidogenesis pathway, making aminoglutethimide valuable for studies focusing on adrenal cortex activity and steroid metabolism. Its precise mechanism offers insights into cortisol regulation at the molecular level. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole (CAS 65277-42-1) is a synthetic imidazole derivative that acts as a potent inhibitor of the cortisol biosynthesis pathway. It functions by inhibiting cytochrome P450 enzymes, particularly CYP11B1, which is involved in the conversion of 11-deoxycortisol to cortisol. This inhibition disrupts the production of cortisol, making ketoconazole valuable in research studies focused on understanding cortisol regulation and enzyme inhibition mechanisms. | ||||||
Etomidate | 33125-97-2 | sc-203577 | 10 mg | $124.00 | ||
Etomidate can inhibit cortisol synthesis by interfering with an enzyme called 11-beta hydroxylase. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $71.00 $163.00 | 1 | |
Mitotane (CAS 53-19-0) is a chemical compound that functions as an inhibitor of cortisol production through the disruption of adrenal cortex cell function. It impacts the biosynthesis of steroid hormones by inhibiting enzymes in the cholesterol pathway, which are essential for cortisol production. This compound is used in scientific research to study the mechanisms regulating adrenal steroidogenesis and to investigate pathways of hormone synthesis modulation. | ||||||
Abiraterone Acetate | 154229-18-2 | sc-207240 | 5 mg | $231.00 | 1 | |
Abiraterone Acetate (CAS 154229-18-2) is a chemical compound known for its ability to inhibit cortisol synthesis. It acts by selectively inhibiting the enzyme 17α-hydroxylase/C17,20-lyase (CYP17A1), which is crucial in the biosynthesis of cortisol from cholesterol. This inhibition reduces the production of cortisol, a steroid hormone involved in various metabolic and stress-related processes. Abiraterone Acetate is commonly used in research for studying cortisol regulation and enzyme interactions. | ||||||
Atrasentan Hydrochloride | 195733-43-8 | sc-503157 | 50 mg | $490.00 | ||
While primarily a selective endothelin receptor antagonist, atrasentan has also been found to reduce cortisol levels by inhibiting the activity of CYP11B1, an enzyme involved in cortisol synthesis. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Studies have suggested that caffeine may decrease cortisol release in response to stress, though its mechanism of action is not entirely clear. | ||||||
Phosphatidyl-L-serine | 51446-62-9 | sc-507548 | 10 g | $45.00 | ||
This is a naturally occurring phospholipid that has been suggested to help reduce cortisol levels and promote a balanced stress response. | ||||||