Coronin 2B Inhibitors
Chemicals classified as Coronin 2B Inhibitors are not direct inhibitors but rather target processes and signaling pathways that Coronin 2B is known to influence. These compounds predominantly affect the cytoskeletal framework of the cell, particularly actin filaments and microtubules, which are critical for maintaining cell shape, enabling cellular movement, and facilitating intracellular transport. By modulating actin dynamics, these inhibitors can indirectly affect the role of Coronin 2B in organizing the actin cytoskeleton, influencing cell motility, and possibly affecting other cellular functions where Coronin 2B is involved.
The chemical inhibitors listed can have a profound impact on cellular actin dynamics. Latrunculin B and Cytochalasin D can cause depolymerization of actin filaments, leading to the disassembly of actin structures with which Coronin 2B interacts. Compounds like CK-666, Swinholide A, and SMIFH2 target actin nucleation and elongation, processes fundamental to the formation and maintenance of the actin cytoskeleton and modulating Coronin 2B's activity. ML141 and NSC 23766 can alter the activity of small GTPases such as Cdc42 and Rac1, which are crucial for actin filament branching and stabilization, processes that could be modulated by Coronin 2B.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers and prevents their polymerization, disrupting the actin cytoskeleton and potentially influencing the function of actin-associated proteins like Coronin 2B. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, blocking polymerization and elongation, which can interfere with actin dynamics and potentially affect Coronin 2B's role in the cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and can lead to abnormal actin polymerization, which may impact Coronin 2B's interaction with actin structures. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits Rho-associated protein kinase (ROCK), which can alter actin cytoskeleton organization and potentially affect Coronin 2B's role in cytoskeletal rearrangements. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II ATPase activity, affecting cell motility and muscle contraction, which may indirectly influence Coronin 2B's function in actin filament modulation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), impacting myosin II activity and actin-myosin contractility, which could affect processes that Coronin 2B is involved in. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
An Arp2/3 complex inhibitor, altering actin polymerization at the leading edge of cells, which can indirectly affect Coronin 2B's function related to actin branching and networking. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits the N-WASP-Arp2/3 interaction, preventing actin polymerization and potentially affecting Coronin 2B's function in actin cytoskeletal dynamics. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Inhibitor of Protein Kinase C (PKC), which is involved in a wide range of cellular functions, including the regulation of cytoskeletal proteins, potentially influencing Coronin 2B's interactions or function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that disrupts vimentin organization, which can influence cytoskeletal dynamics and thereby potentially impact Coronin 2B's activity. | ||||||