Coronin 2A Inhibitors
Coronin 2A inhibitors belong to a specialized chemical class that targets the Coronin 2A protein, a crucial regulator of cellular processes. The Coronin family of proteins is characterized by their involvement in actin dynamics and cytoskeletal rearrangements, playing a pivotal role in cellular motility and immune response. Specifically, Coronin 2A, a member of this family, is implicated in the modulation of F-actin organization and cellular migration. Inhibitors designed to selectively target Coronin 2A function operate by disrupting its regulatory activity, thereby influencing the intricate balance of actin polymerization and depolymerization within the cell.
These inhibitors typically exhibit a high degree of specificity for Coronin 2A, distinguishing them from compounds that may interact with other Coronin family members. The design and synthesis of Coronin 2A inhibitors involve a meticulous understanding of the protein's structural and functional characteristics, allowing for the development of compounds with enhanced affinity and selectivity. Researchers employ a range of techniques, including structure-activity relationship studies and computational modeling, to optimize the pharmacological properties of these inhibitors. By elucidating the molecular interactions between the inhibitor and Coronin 2A, scientists aim to advance our understanding of the intricate regulatory networks governing cellular motility, paving the way for further insights into the broader implications of Coronin 2A inhibition in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, preventing polymerization and thus potentially altering CORO2A function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Sequesters G-actin monomers, preventing their incorporation into filaments, which may interfere with CORO2A's role in actin dynamics. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
A dimeric actin-depolymerizing compound, which can disrupt actin structures and potentially affect CORO2A-related processes. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments and could indirectly affect CORO2A by altering actin dynamics. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
An Arp2/3 complex inhibitor that can alter actin polymerization and thereby possibly influence CORO2A activity. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
An inhibitor of formin homology 2 domains, might affect CORO2A by altering the formation of actin filaments. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, which can affect actin cytoskeleton dynamics and possibly CORO2A's associated activities. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II, and can thus alter cellular processes where CORO2A is involved. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), which is involved in actin-myosin contraction and might influence CORO2A function. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
A specific inhibitor of the neuronal Wiskott-Aldrich syndrome protein (N-WASP), which can influence actin assembly and potentially affect CORO2A. | ||||||