COQ10B Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin inhibits HMG-CoA reductase, a rate-determining enzyme in the biosynthesis of coenzyme Q10 (CoQ10). Since COQ10B is involved in the biosynthesis of CoQ10, the reduction of CoQ10 precursor levels due to atorvastatin can functionally inhibit COQ10B by limiting its substrate availability. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, another HMG-CoA reductase inhibitor, decreases the synthesis of mevalonate, a precursor in the CoQ10 biosynthesis pathway. This would result in a lower availability of substrates required for COQ10B function, thereby functionally inhibiting it. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $142.00 | 8 | |
Rosuvastatin works similarly to other statins by inhibiting HMG-CoA reductase. By limiting the synthesis of mevalonic acid, the availability of substrates for COQ10B is decreased, which functionally inhibits the enzymatic activity of COQ10B in the CoQ10 biosynthesis process. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits the HMG-CoA reductase enzyme, which is upstream in the CoQ10 biosynthetic pathway. By doing so, it reduces the levels of intermediates required for COQ10B activity, effectively functionally inhibiting COQ10B. | ||||||
Pravastatin, Sodium Salt | 81131-70-6 | sc-203218 sc-203218A sc-203218B | 25 mg 100 mg 1 g | $68.00 $159.00 $772.00 | 2 | |
Pravastatin inhibits HMG-CoA reductase, leading to a reduction in mevalonate, and ultimately ubiquinone (CoQ10) precursors. This results in functionally inhibiting COQ10B by starving it of its necessary substrates. | ||||||
Fluvastatin | 93957-54-1 | sc-279169 | 50 mg | $250.00 | ||
Fluvastatin's inhibition of HMG-CoA reductase ultimately reduces the levels of farnesyl-PP and isoprenoids, essential substrates for CoQ10 biosynthesis, which COQ10B is a part of. This functionally inhibits COQ10B by reducing substrate availability. | ||||||
Cerivastatin, Sodium Salt | 143201-11-0 | sc-207418 | 2.5 mg | $175.00 | ||
Cerivastatin inhibits HMG-CoA reductase, which decreases the production of mevalonate and its downstream products necessary for CoQ10 biosynthesis. This lack of substrates functionally inhibits COQ10B. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $75.00 $175.00 | 18 | |
Mevastatin inhibits HMG-CoA reductase, thereby reducing the synthesis of mevalonate, a vital precursor in CoQ10 biosynthesis. This limits the substrates necessary for COQ10B function, resulting in its functional inhibition. | ||||||
1-Aminobenzotriazole | 1614-12-6 | sc-200600 sc-200600A | 50 mg 100 mg | $60.00 $131.00 | 6 | |
Aminobenzotriazole is a non-selective inhibitor of cytochrome P450 enzymes, which can be involved in the post-translational modifications necessary for COQ10B function. Inhibition of these enzymes can thus functionally inhibit COQ10B by preventing its proper modification and subsequent activity. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
Diphenyleneiodonium chloride inhibits flavoenzymes, which can include those involved in the biosynthesis of CoQ10. Inhibition of these enzymes can lead to functional inhibition of COQ10B by disrupting the electron transfer required for its enzymatic activity. | ||||||