copine 4 Activators
Copine 4 activators represent a category of compounds that specifically target and modulate the activity of Copine 4, a member of the copine family, which is characterized by calcium-dependent membrane-binding proteins. Copine 4, like other members of its family, contains two C2 domains and an A domain, resembling von Willebrand factor type A domains found in various membrane and cytosolic proteins. These domains suggest a role in calcium-dependent phospholipid binding and potentially in signal transduction pathways, where Copine 4 may mediate cellular responses to external stimuli by interacting with various signaling molecules and membrane components. The precise physiological functions of Copine 4 are still being elucidated, but it is believed to be involved in processes such as cell migration, adhesion, and possibly in the regulation of gene expression. Activators of Copine 4 are designed to enhance its biological activity, potentially influencing these cellular processes. The chemical structures of Copine 4 activators can vary widely, from small organic molecules to larger biochemical compounds, each tailored to interact specifically with Copine 4, thereby modulating its function within cells.
The investigation of Copine 4 activators involves a multi-faceted approach that incorporates techniques from cell biology, biochemistry, and molecular pharmacology to elucidate the effects of these compounds on Copine 4 function and cellular activity. Researchers study the interaction between Copine 4 and its activators by examining changes in Copine 4's membrane association, its interaction with other cellular proteins, and its involvement in signaling pathways. This might include the use of lipid overlay assays to assess phospholipid binding in the presence of calcium, co-immunoprecipitation studies to identify interacting partners, and reporter assays to evaluate the impact on gene expression. Additionally, cellular assays that monitor changes in cell morphology, migration, and adhesion can provide insights into the functional consequences of Copine 4 activation. Through these studies, scientists aim to gain a deeper understanding of Copine 4's role in cellular processes and how modulation of its activity by specific activators can impact cell behavior, contributing to the broader knowledge of calcium-dependent signaling and membrane dynamics in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
May modulate gene expression by affecting signal transduction pathways and transcription factors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which can modulate transcription factor activity and gene expression. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
The active form of vitamin D that binds to vitamin D receptors, influencing the expression of target genes. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
An antioxidant that could affect gene expression through its role in cellular redox balance and enzymatic cofactor functions. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
May influence gene expression by inhibiting NF-κB signaling, which plays a role in the regulation of numerous genes. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
A cAMP analog that can permeate cell membranes and mimic the action of cAMP, affecting transcription factor activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A vitamin A derivative that can bind to retinoic acid receptors, modulating gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, which may influence transcription factors and gene expression. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Often used as a solvent, DMSO can also affect cellular processes and gene expression patterns. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can lead to DNA demethylation and affect gene expression. | ||||||