connexin 45 Inhibitors
Connexin 45 (Cx45) is an integral membrane protein that forms gap junction channels, facilitating direct intercellular communication between adjacent cells. These channels allow for the passage of ions, second messengers, and small metabolites, enabling coordinated responses and maintaining tissue homeostasis. Cx45 is widely expressed in various tissues, including the heart and the nervous system, where it plays a crucial role in propagating electrical impulses and synchronizing cardiac muscle contraction, as well as modulating neurotransmitter release in neuronal cells. The functional specificity of Cx45, characterized by its unique gating properties and selective permeability, underlines its importance in the precise regulation of cellular communication and the development and function of complex tissue systems.
The inhibition of Cx45 activity disrupts gap junctional intercellular communication, which can have significant implications for tissue function and homeostasis. Mechanisms of Cx45 inhibition encompass a range of strategies, including genetic manipulation such as gene knockdown or knockout techniques, which inhibits the expression of Cx45, and the application of pharmacological agents that specifically target gap junction channels. Additionally, post-translational modifications of Cx45, such as phosphorylation, can modulate channel gating and assembly, thereby influencing channel function and intercellular communication. Environmental factors, including changes in pH and calcium ion concentration, can also regulate Cx45 channel activity by altering channel conformation and stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Carbenoxolone is a derivative of glycyrrhetinic acid and is known for its inhibitory effects on connexin channels. It has been shown to block gap junction communication by inhibiting connexin hemichannel activity. Carbenoxolone is thought to modulate connexin channels by affecting their permeability, thus disrupting the normal cell-to-cell communication mediated by gap junctions. | ||||||
Mefloquine Hydrochloride | 51773-92-3 | sc-211784 | 100 mg | $118.00 | 4 | |
Mefloquine, an antimalarial drug, has been identified as a potential inhibitor of connexin channels. It is suggested to modulate gap junction communication, including those involving connexin 45. The precise mechanism of action is not fully elucidated, but studies propose that mefloquine can influence connexin channels by altering their conductance properties. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has been identified as a modulator of connexin channels, potentially impacting connexin 45. It is suggested to inhibit gap junction communication by affecting the opening and closing of connexin channels. The specific mechanism involves the blockade of connexin hemichannels, leading to the disruption of intercellular communication. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine, an antimalarial alkaloid, has been explored for its potential inhibitory effects on connexin channels, including those mediated by connexin 45. Although the precise mechanism is not fully understood, quinine is proposed to modulate gap junction communication by influencing the conductance of connexin channels. This indirect modulation may disrupt the normal intercellular signaling mediated by connexin 45. | ||||||
Diclofenac Sodium | 15307-79-6 | sc-202136 sc-202136A | 5 g 25 g | $41.00 $128.00 | 4 | |
Diclofenac, a widely used NSAID, has been implicated as a modulator of connexin channels, potentially affecting connexin 45. The exact mechanism of action is not fully elucidated, but studies suggest that diclofenac can alter gap junction communication by influencing connexin channel permeability. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) is a compound known for its modulatory effects on various ion channels and receptors, including connexin channels. Although a specific CAS Number is not available, it is included for its relevance. 2-APB is suggested to influence connexin channels by modifying their conductance properties. This modulation may lead to the inhibition of connexin 45-mediated gap junction communication. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic acid, a diuretic, has been identified as a potential modulator of connexin channels, including those involving connexin 45. It is suggested to affect gap junction communication by influencing the opening and closing of connexin channels. The specific mechanism involves the blockade of connexin hemichannels, leading to the disruption of intercellular communication. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium chloride is a compound known for its inhibitory effects on various ion channels, including connexin hemichannels. Although a specific CAS Number is not available, it is included for its relevance. Gadolinium chloride is suggested to modulate connexin channels by affecting their conductance properties. This modulation may lead to the inhibition of connexin 45-mediated gap junction communication. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone, a mitochondrial complex I inhibitor, has been explored for its potential inhibitory effects on connexin channels, including those mediated by connexin 45. The specific mechanism of action is not fully elucidated, but rotenone is proposed to modulate gap junction communication by influencing connexin channel conductance. | ||||||