connexin 45 Antibody (G-7): sc-374354

connexin 45 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects connexin 45 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-connexin 45 antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Connexin 45 plays a crucial role in forming gap junctions, which are essential for intercellular communication, allowing the passage of ions and small molecules between adjacent cells. This function is particularly important in cardiac tissue, where connexin 45 contributes to electrical coupling necessary for synchronized heart contractions. Disruption of connexin 45 expression can lead to impaired cardiac function and has been associated with various cardiac pathologies, including heart failure. Connexin 45′s structure, characterized by four transmembrane α-helical domains and specific extracellular loops, is vital for forming functional channels that regulate cellular communication. Each connexin isoform, including connexin 45, exhibits unique properties that influence permeability and response to signaling molecules, underscoring the importance of connexin diversity in maintaining tissue homeostasis and function.

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connexin 45 Antibody (G-7) References:

1. Altered connexin expression in human congestive heart failure.  |  Dupont, E., et al. 2001. J Mol Cell Cardiol. 33: 359-71. PMID: 11162139
2. Emerging issues of connexin channels: biophysics fills the gap.  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
3. Neuregulin-1 increases connexin-40 and connexin-45 expression in embryonic stem cell-derived cardiomyocytes.  |  Wang, Z. and Huang, J. 2014. Appl Biochem Biotechnol. 174: 483-93. PMID: 25080381
4. Progressive Atrial Conduction Defects Associated With Bone Malformation Caused by a Connexin-45 Mutation.  |  Seki, A., et al. 2017. J Am Coll Cardiol. 70: 358-370. PMID: 28705318
5. Connexin-45 as a New Gene Underlying Syndromic AV Block.  |  Ellinor, PT. and Jameson, HS. 2017. J Am Coll Cardiol. 70: 371-372. PMID: 28705319
6. Human cardiac gap junctions: isolation, ultrastructure, and protein composition.  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042
7. Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies.  |  Schulz, B., et al. 2023. BMC Cancer. 23: 232. PMID: 36899312
8. Connexin 45 is a novel suppressor of melanoma metastasis.  |  Saito, M., et al. 2023. Cytotechnology. 75: 103-113. PMID: 36969569
9. Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function.  |  Davis, MJ., et al. 2024. JCI Insight. 9: PMID: 39074069
10. Muscle-restricted knockout of connexin 43 and connexin 45 accelerates and improves locomotor recovery after contusion spinal cord injury.  |  Toro, CA., et al. 2024. Front Physiol. 15: 1486691. PMID: 39524606
11. Decreased connexin expression and intercellular communication in human bladder cancer cells.  |  Grossman, HB., et al. 1994. Cancer Res. 54: 3062-5. PMID: 8187096
12. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart.  |  Coppen, SR., et al. 1998. Circ Res. 82: 232-43. PMID: 9468194

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 45 Antibody (G-7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 45 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 45 Antibody (G-7) Specifications

Alternate Product Name: GJC1

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 251-335

Epitope Target: connexin 45

Epitope Species: human

Product Reactivity/Detection: connexin 45

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for connexin 45 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin