connexin 33 Inhibitors
Connexin 33 inhibitors are chemical compounds that selectively target and inhibit the activity of connexin 33, a member of the connexin protein family. Connexins are integral membrane proteins that form gap junctions, which are specialized structures that allow direct intercellular communication by permitting the passage of ions, metabolites, and small signaling molecules between adjacent cells. Connexin 33, like other connexins, assembles into hexameric complexes known as connexons. These connexons can dock with connexons from neighboring cells to form gap junction channels. While most connexins are involved in regulating tissue homeostasis, ion balance, and signal transmission, connexin 33 has distinct structural and regulatory properties that set it apart from other family members, although its precise biological functions are less well understood compared to more studied connexins like connexin 43.
Inhibitors of connexin 33 specifically interfere with the ability of this protein to form functional gap junctions, thereby disrupting intercellular communication in cells expressing connexin 33. The inhibition of connexin 33 can be achieved by small molecules, peptides, or other chemical agents that either bind directly to the protein or prevent its assembly into functional channels. Connexin 33 expression and function have been shown to be highly tissue-specific, and this selectivity in expression patterns makes connexin 33 inhibitors particularly important for studying the protein's unique role in specific biological processes. These inhibitors are useful in exploring the regulatory mechanisms behind gap junction formation, intercellular signaling, and cellular coordination in systems where connexin 33 is active, providing valuable insight into its role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Carbenoxolone, a gap junction inhibitor, directly interferes with connexin 33 function by blocking gap junction channel activity. This inhibition disrupts cell-cell signaling mediated by connexin 33, influencing intercellular communication within gap junctions. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone, a mitochondrial complex I inhibitor, indirectly influences connexin 33 by disrupting mitochondrial function. This interference impacts cellular processes related to cell-cell signaling and gap junction channel activity, potentially modulating connexin 33 function. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid, an organic anion transporter inhibitor, serves as an indirect connexin 33 inhibitor by affecting cellular transport mechanisms. This interference impacts cell-cell signaling and gap junction channel activity, potentially modulating connexin 33 function. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl Borate, an inositol trisphosphate receptor inhibitor, directly influences connexin 33 by affecting calcium signaling. This interference disrupts cell-cell signaling and gap junction channel activity, potentially modulating connexin 33 function. | ||||||
2-Bromo-2-chloro-1,1,1-trifluoroethane | 151-67-7 | sc-251705 sc-251705A | 125 ml 250 ml | $172.00 $300.00 | ||
2-Bromo-2-chloro-1,1,1-trifluoroethane (Halothane), a volatile anesthetic, indirectly influences connexin 33 by affecting cellular processes related to gap junction channel activity. This interference impacts cell-cell signaling, potentially modulating connexin 33 function. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365, a store-operated calcium entry inhibitor, directly influences connexin 33 by affecting calcium signaling. This interference disrupts cell-cell signaling and gap junction channel activity, potentially modulating connexin 33 function. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $150.00 $350.00 | 4 | |
Gadolinium Chloride, a gap junction channel blocker, serves as a direct connexin 33 inhibitor by blocking gap junction channel activity. This interference disrupts cell-cell signaling mediated by connexin 33, influencing intercellular communication within gap junctions. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $113.00 $454.00 | 3 | |
CGP-37157, a mitochondrial Na+/Ca2+ exchanger inhibitor, indirectly influences connexin 33 by affecting mitochondrial calcium handling. This interference impacts cellular processes related to cell-cell signaling and gap junction channel activity, potentially modulating connexin 33 function. | ||||||