Date published: 2025-12-8

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COMMD10 Inhibitors

COMMD10 inhibitors are compounds that work to reduce the activity of COMMD10, a protein involved in various cellular processes regulated by specific signaling pathways. Staurosporine, a broad-spectrum kinase inhibitor, hinders the phosphorylation of COMMD10's substrates, thereby reducing its downstream signaling and functional activity. LY294002 and Wortmannin are PI3K inhibitors that block the PI3K/Akt pathway. As COMMD10 is involved in this pathway, the inhibition leads to a decrease in COMMD10 activity. U0126 and PD98059 are MEK inhibitors that suppress the ERK1/2 pathway. COMMD10's function is tied to this pathway, so its activity is reduced when these inhibitors are present. Rapamycin and AZD8055 are mTOR inhibitors that disrupt the mTOR pathway, leading to decreased COMMD10 activity as COMMD10 is involved in this pathway. SP600125 is a JNK inhibitor that dampens JNK signaling, a pathway that COMMD10 is involved in, leading to decreased COMMD10 functional activity. SB203580 is a p38 MAPK inhibitor whose action inhibits the p38 MAPK pathway, leading to decreased COMMD10 activity. GSK690693 is an Akt inhibitor that disrupts the PI3K/Akt pathway, leading to decreased COMMD10 activity. BAY 11-7082 is an NF-kB inhibitor that disrupts the NF-kB pathway, leading to decreased COMMD10 activity. Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK). Its action disrupts the Rho/ROCKpathway, which COMMD10 is involved in, leading to decreased COMMD10 activity.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine is a broad-spectrum kinase inhibitor that hinders the phosphorylation of COMMD10's substrates, thereby reducing its downstream signaling and functional activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor that blocks the PI3K/Akt pathway. Since COMMD10 has a role in this pathway, the inhibition of the pathway leads to decreased COMMD10 activity.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 is a MEK1 and MEK2 inhibitor. By inhibiting these kinases, it suppresses the ERK1/2 pathway, which has ties to COMMD10 activity, leading to the reduction of COMMD10′s function.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is a selective MEK inhibitor. Its inhibition of MEK suppresses ERK signaling, a pathway in which COMMD10 is involved, leading to a decrease in COMMD10 functional activity.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin is an mTOR inhibitor. By inhibiting mTOR, it disrupts the mTOR pathway, which COMMD10 is involved in, leading to decreased COMMD10 activity.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a JNK inhibitor. Its inhibition of JNK dampens JNK signaling, a pathway that COMMD10 is involved in, leading to decreased COMMD10 functional activity.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAPK inhibitor. Its action inhibits the p38 MAPK pathway, leading to decreased COMMD10 activity as COMMD10 is involved in this pathway.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a potent PI3K inhibitor. It inhibits the PI3K/Akt pathway, which COMMD10 is involved in, leading to decreased COMMD10 activity.

AZD8055

1009298-09-2sc-364424
sc-364424A
10 mg
50 mg
$160.00
$345.00
12
(2)

AZD8055 is a potent mTOR inhibitor. It disrupts the mTOR pathway, which COMMD10 is involved in, leading to decreased COMMD10 activity.

GSK 690693

937174-76-0sc-363280
sc-363280A
10 mg
50 mg
$255.00
$1071.00
4
(1)

GSK690693 is an Akt inhibitor. Its inhibition of Akt disrupts the PI3K/Akt pathway, which COMMD10 is involved in, leading to decreased COMMD10 activity.