COL4A6 Activators
COL4A6 Activators are an array of chemical entities that specifically augment the functional activation of the COL4A6 protein, a component of type IV collagen involved in the integrity of basement membranes. One activator might be a compound that stabilizes the triple-helical structure of collagen, such as a peptidomimetic that binds to the collagen and prevents enzymatic breakdown, thus indirectly enhancing COL4A6's role in the extracellular matrix. Another activator could be a small molecule that facilitates the hydroxylation of proline residues within COL4A6, an essential post-translational modification required for collagen stability, which is achieved by enhancing the activity of prolyl hydroxylase or by stabilizing the iron center of the enzyme, ensuring the structural integrity and function of COL4A6. Additionally, there could be a molecule designed to inhibit collagenase activity, which would indirectly result in increased levels of functional COL4A6 by decreasing its degradation.
Further, the functionality of COL4A6 could be enhanced by chemical agents that promote the cross-linking of collagen fibers, such as those that increase the activity of lysyl oxidase, an enzyme crucial for the covalent bonding that stabilizes the collagen network. There might also be a signaling molecule that increases the expression of integrins that interact with COL4A6, facilitating cell adhesion and signaling that is dependent on the intact basement membrane structure. Moreover, small molecules that modulate the assembly of collagen fibrils could act as activators by increasing the efficiency of COL4A6 incorporation into the extracellular matrix. Collectively, these activators enhance the structural and functional role of COL4A6, by focusing on preserving the protein's stability and its integration into the basement membrane, maintaining tissue architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is essential for the hydroxylation of proline and lysine residues in collagen molecules, a critical post-translational modification necessary for the stability and function of collagen. Enhanced hydroxylation by ascorbic acid can therefore increase the structural integrity and function of COL4A6 in the extracellular matrix. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is a cofactor for lysyl oxidase, an enzyme that cross-links collagen molecules. Copper sulfate can thus enhance the cross-linking of COL4A6, strengthening the collagen network. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $40.00 $105.00 | ||
Manganese is a necessary cofactor for prolidase, an enzyme involved in collagen synthesis and recycling. By supporting prolidase activity, manganese(II) sulfate can promote the synthesis and deposition of COL4A6. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $102.00 | ||
This compound acts as a lysyl oxidase inhibitor. Inhibition of lysyl oxidase can lead to a compensatory upregulation of collagen synthesis, potentially enhancing the availability and deposition of COL4A6. | ||||||
Lactic acid | 50-21-5 | sc-215227 sc-215227A | 100 ml 500 ml | $100.00 $175.00 | 1 | |
Lactic acid stimulates the synthesis of collagens by fibroblasts. This can lead to the increased production of COL4A6 by these cells, enhancing its presence in the extracellular matrix. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates the expression of genes involved in collagen production. By influencing gene expression, retinoic acid can enhance the synthesis of COL4A6. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can reduce the degradation of collagen by inhibiting enzymes that break down extracellular matrix components. This could indirectly lead to an increased functional activity of COL4A6 by preserving the existing collagen matrix. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic acid acts on fibroblasts to stimulate the production of collagens. Increasing the synthesis of collagen can enhance the functional activity of COL4A6 in tissue structure and repair. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $204.00 | ||
While not directly enhancing COL4A6, hyaluronic acid can influence the extracellular matrix environment, potentially promoting better integration and function of COL4A6 within the matrix. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine can stabilize the triple helical structure of collagen and protect it from thermal denaturation. This can enhance the structural integrity of COL4A6. | ||||||