COL4A4 Activators
COL4A4 activators are a group of chemical agents designed to modulate the activity of the COL4A4 protein, a type IV collagen specifically associated with the basement membrane, a specialized form of extracellular matrix (ECM). The COL4A4 protein, along with COL4A3 and COL4A5, forms a triple helical structure that is essential for the mechanical stability and function of the basement membranes in various tissues. These membranes are crucial for processes such as filtration in the kidneys, structural support in muscle tissue, and the formation of stable, functional interfaces in various organ systems.
Direct activators of COL4A4 may interact with the protein or the cells that produce it to enhance the synthesis, assembly, or stabilization of the collagen IV network. Such activators could stimulate the transcription of the COL4A4 gene, promote the translation of its mRNA, or enhance the post-translational modifications and proper folding of the protein into its triple helical structure. They might also prevent the enzymatic degradation of COL4A4 or facilitate the correct assembly of collagen IV molecules into the mesh-like structure of the basement membrane. Indirect activators could influence the activity of COL4A4 through signaling pathways that regulate the production of extracellular matrix components or through the modulation of factors that control the cross-linking and integration of collagen fibers into the ECM. For instance, they might affect the activity of enzymes that are responsible for the post-translational modifications of collagen, or they could alter the expression of other ECM proteins that interact with collagen IV, thus affecting the overall integrity and function of the basement membrane.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $146.00 $437.00 $478.00 $754.00 $1446.00 | 3 | |
Methylglyoxal is a highly reactive dicarbonyl compound that can form AGEs, which interact with RAGE receptors to activate intracellular signaling cascades, including the MAPK/ERK pathway. This activation enhances the expression of collagen IV, the protein product of COL4A4. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
High glucose levels stimulate the formation of AGEs. These AGEs interact with RAGE receptors, activating pathways like the MAPK/ERK pathway that enhance the expression of collagen IV, the protein product of COL4A4. | ||||||
D-Galactose | 59-23-4 | sc-202564 | 100 g | $288.00 | 4 | |
Galactose can be converted into glucose in the body, which can then lead to the formation of AGEs. These AGEs activate intracellular pathways through RAGE, including the MAPK/ERK pathway, leading to the increased expression of collagen IV, the protein product of COL4A4. | ||||||
D-(−)-Ribose | 50-69-1 | sc-221458 sc-221458A sc-221458B sc-221458C sc-221458D sc-221458E sc-221458F | 5 g 25 g 100 g 250 g 1 kg 5 kg 10 kg | $26.00 $58.00 $112.00 $235.00 $612.00 $1224.00 $2040.00 | 1 | |
Ribose can lead to the formation of AGEs, which bind to RAGE receptors. The activation of these receptors triggers intracellular pathways such as the MAPK/ERK pathway, enhancing the expression of collagen IV, the protein product of COL4A4. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA acts on its receptors to activate several signaling pathways, including the PI3K/Akt pathway, which can lead to the activation of mTOR. This activation enhances the synthesis of collagen IV, the protein product of COL4A4. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt pathway, which can lead to the activation of mTOR. This activation enhances the synthesis of collagen IV, the protein product of COL4A4. | ||||||
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $106.00 $244.00 $417.00 | ||
PA binds to mTOR directly, activating this pathway and enhancing the synthesis of collagen IV, the protein product of COL4A4. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its receptors to activate several signaling pathways, including the PI3K/Akt pathway, which can lead to the activation of mTOR. This activation enhances the synthesis of collagen IV, the protein product of COL4A4. | ||||||