COL4A3 Inhibitors
COL4A3 inhibitors are a class of chemical compounds that specifically target and interact with the COL4A3 gene, which encodes one of the alpha chains of type IV collagen. Type IV collagen is a major structural component of the basement membranes in various tissues, including the kidney glomerulus, inner ear, and eyes. These inhibitors are designed to modulate the expression or activity of COL4A3, leading to changes in the synthesis and assembly of type IV collagen. By inhibiting COL4A3, these compounds can disrupt the formation of normal collagen networks, which play a crucial role in maintaining tissue integrity and function.
The inhibition of COL4A3 can have profound effects on tissue architecture and function. In particular, alterations in the composition or structure of type IV collagen can lead to impaired basement membrane integrity and increased permeability, resulting in various pathological conditions. COL4A3 inhibitors may find applications in research aimed at understanding the role of type IV collagen in various diseases and developmental processes. Additionally, they may serve as valuable tools for investigating the consequences of basement membrane dysfunction in different tissues, shedding light on the molecular mechanisms underlying diseases associated with COL4A3 mutations or dysregulation. COL4A3 inhibitors use as research reagents holds promise for advancing our knowledge of basement membrane biology and related diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1740.00 | ||
Halofuginone inhibits the synthesis of collagen types I, II, and IV by blocking the TGF-β pathway, potentially reducing COL4A3 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is reported to downregulate the expression of several genes, including those coding for type IV collagen, potentially through its anti-inflammatory and antioxidant effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, may exert its inhibitory effects on COL4A3 expression through antioxidant activity and modulation of various signaling pathways. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan may downregulate COL4A3 expression by blocking the action of angiotensin II, which has been shown to stimulate the production of extracellular matrix components, including type IV collagen. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which can lead to a decrease in protein synthesis, potentially including the synthesis of COL4A3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may inhibit COL4A3 expression through its anti-inflammatory effects and by modulating the activity of transcription factors that control collagen synthesis. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone may reduce COL4A3 expression by antagonizing aldosterone, which can induce the expression of collagen and other extracellular matrix proteins. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen is known for its antiestrogenic effects and may reduce the expression of COL4A3 by affecting estrogen-mediated signaling. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide is known to modulate immune responses and inhibit angiogenesis, which may lead to decreased COL4A3 expression. | ||||||