COL4A3 Activators
COL4A3 Activators refer to a category of chemical compounds that interact with and modulate the function of the COL4A3 gene. The COL4A3 gene encodes for one of the collagen type IV alpha chains, which are essential components of basement membranes in various tissues throughout the body, particularly in the kidneys and inner ear. These activators exert their influence at the molecular level by promoting the transcription, translation, or stabilization of COL4A3 mRNA or protein. The activation of COL4A3 is of particular interest because it is crucial for the formation and maintenance of basement membranes, which serve as structural scaffolds and play vital roles in tissue integrity and function.
COL4A3 activators may function through a variety of mechanisms, including the binding to specific regulatory elements within the COL4A3 gene or its promoter region, thereby enhancing gene expression. Alternatively, these activators may interact with proteins or cellular pathways that indirectly promote COL4A3 synthesis or stability. The activation of COL4A3 is significant because disruptions in collagen type IV alpha chain assembly can lead to various pathological conditions, including Alport syndrome, a hereditary kidney disease characterized by abnormal basement membrane structure. By targeting COL4A3, these activators influence the synthesis and organization of collagen type IV, with implications for tissue development, repair, and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid, or Vitamin C, is crucial for collagen synthesis. It acts as a cofactor for prolyl and lysyl hydroxylase, enzymes that are essential for the post-translational modification of collagen. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences collagen gene expression. It has been shown to modulate the synthesis of various types of collagens, possibly including COL4A3. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is a cofactor for lysyl oxidase, an enzyme involved in collagen cross-linking. Copper sulfate supplementation can indirectly affect collagen stability and function. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Manganese is a cofactor for prolidase, an enzyme important for collagen synthesis. Its presence is crucial for the proper formation and remodeling of collagen. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $45.00 $94.00 | ||
This drug is known to break disulfide bonds in collagen, thus altering collagen structure. It might indirectly affect COL4A3 by modifying extracellular matrix dynamics. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a phytoestrogen, has been shown to affect collagen synthesis and might influence the expression or function of COL4A3 indirectly. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $204.00 | ||
While not a direct activator, hyaluronic acid is involved in extracellular matrix organization and may influence the environment around COL4A3. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine is a major component of collagen. Supplementing glycine might influence collagen structure and potentially affect COL4A3. | ||||||