COL28A1 Activators
Chemical activators of COL28A1 encompass a range of compounds that participate in or facilitate the synthesis, post-translational modification, and maturation of the collagen triple helix structure. The activities of these compounds span from the provision of substrates for collagen synthesis, such as amino acids and vitamin C, to the supply of essential cofactors for enzymes that are critical in the post-translational modification and cross-linking of collagen fibers. Through these mechanisms, these chemicals create an environment conducive to the stabilization and proper assembly of collagen fibers, including the specialized form of collagen, COL28A1.
Furthermore, the regulation of collagen synthesis at the genetic level can be influenced by retinoic acid, which adjusts the transcription of genes involved in collagen production. Trace elements like copper, manganese, and silicon are integral to enzyme functions that cross-link and mature collagen, suggesting their roles extend to all collagen types.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is required for the hydroxylation of proline and lysine residues in collagen, which is necessary for the stability of the collagen triple helix, including that of COL28A1. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is a cofactor for lysyl oxidase, an enzyme responsible for the cross-linking of collagen molecules, which is essential for the formation of stable collagen fibers including COL28A1. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese is a cofactor for prolidase, an enzyme involved in the recycling of proline for collagen synthesis, thus potentially enhancing the production of COL28A1. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
α-Ketoglutarate is a substrate for prolyl-4-hydroxylase, a key enzyme in collagen synthesis, supporting the hydroxylation step crucial for COL28A1 stability. | ||||||
Iron | 7439-89-6 | sc-215190 sc-215190A | 500 g 2 kg | $69.00 $180.00 | ||
Iron is a required cofactor for prolyl and lysyl hydroxylase enzymes, essential in post-translational modification of collagens, including COL28A1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression and enhance collagen production by fibroblasts, which could increase the synthesis of COL28A1. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been shown to enhance autophagy and protein synthesis, which could indirectly support the production and turnover of collagen, including COL28A1. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
Lysine is a crucial amino acid in collagen triple helix formation and can provide the necessary substrate for the lysine hydroxylation and subsequent cross-linking in COL28A1. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
Proline provides a substrate for prolyl-4-hydroxylase, supporting the synthesis and stability of the COL28A1 triple helix structure. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine is a major constituent of collagen; increased availability can support collagen synthesis, including the formation of COL28A1. | ||||||