COL23A1 Activators
Collagen, type XXIII, alpha 1 (COL23A1) activators are compounds that enhance the synthesis, post-translational modifications, and assembly of the COL23A1 protein. Ascorbic acid is crucial for the hydroxylation of proline residues in COL23A1, a modification vital for the stability and function of the collagen triple helix. Copper(II) sulfate enhances the activity of lysyl oxidase, an enzyme necessary for the cross-linking of collagen fibers, thus contributing to the structural integrity of COL23A1. Similarly, α-Ketoglutarate provides the necessary substrate for prolyl hydroxylase, which modifies COL23A1, and succinic acid, as part of the TCA cycle, supplies energy and intermediates crucial for collagen synthesis. Iron(II) sulfate and manganese(II) chloride serve as cofactors for enzymes involved in the post-translational modification and processing of COL23A1, ensuring its proper formation and function.
The structural components of COL23A1 such as glycine, proline, lysine, serine, and threonine are directly incorporated into the protein during its synthesis, influencing the stability and function of the collagen. Glycine forms a significant part of the collagen triple helix, while proline and lysine undergo specific modifications essential for collagen integrity. Serine and threonine are substrates for glycosylation, a modification that affects the structure and function of COL23A1. Finally, zinc sulfate contributes to the remodeling process of collagen by serving as a cofactor for collagenase enzymes, thereby indirectly influencing the functional activity of COL23A1 through collagen turnover and tissue remodeling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is essential for the hydroxylation of proline residues during the synthesis of collagen, including COL23A1. It directly supports the post-translational modifications necessary for the proper folding and stability of COL23A1. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is a cofactor for lysyl oxidase, the enzyme responsible for cross-linking collagen molecules, including COL23A1. Copper(II) sulfate can enhance the enzymatic activity, thus indirectly enhancing the structural integrity of COL23A1 fibers. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
α-Ketoglutarate is a substrate for prolyl hydroxylase, which hydroxylates specific proline residues on COL23A1, a post-translational modification necessary for collagen maturation and function. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinic acid is involved in the TCA cycle, which provides the necessary energy and intermediates for collagen synthesis, including COL23A1. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $72.00 $107.00 | ||
Iron is a required cofactor for prolyl and lysyl hydroxylases, which are essential for the post-translational modification of collagens such as COL23A1. Iron(II) sulfate thereby supports the stability and function of COL23A1. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese is a cofactor for several enzymes involved in the post-translational processing of collagen, including prolidase, which recycles proline for collagen synthesis, thus supporting COL23A1 production. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine is a major constituent of collagen triple helix structure and is directly incorporated into COL23A1 during its synthesis. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $37.00 $130.00 $204.00 $959.00 | ||
Proline is hydroxylated and incorporated into COL23A1, which is necessary for the stability of the collagen triple helix. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $93.00 $258.00 $519.00 | ||
Lysine residues in COL23A1 are hydroxylated and glycosylated, which are critical steps for the structural integrity and function of this collagen. | ||||||
L-Serine | 56-45-1 | sc-397670 sc-397670A sc-397670B sc-397670C sc-397670D | 1 g 100 g 1 kg 5 kg 10 kg | $20.00 $130.00 $535.00 $1200.00 $2000.00 | ||
Serine serves as a substrate for the glycosylation of certain residues in collagens, including COL23A1, which is essential for its structure and function. | ||||||