COL23A1 Antibody (C-10): sc-514835

COL23A1 Antibody (C-10) is a mouse monoclonal IgM antibody that detects COL23A1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-COL23A1 antibody (C-10) is available as a non-conjugated antibody. COL23A1, also known as collagen alpha-1 (XXIII) chain, is a crucial component of the extracellular matrix, functioning primarily as a single-pass type II membrane protein that forms a homotrimer. COL23A1 consists of 540 amino acids and features five collagen-like domains, which are essential for structural integrity and function. These domains allow COL23A1 to participate in the formation of complex connective tissues, contributing to the overall architecture and mechanical properties of tissues such as tendons and cartilage. COL23A1 undergoes alternative splicing, resulting in two distinct isoforms, which may have different functional roles in tissue development and repair. The gene encoding COL23A1 is located on human chromosome 5, highlighting evolutionary significance and potential implications in various biological processes. Anti-COL23A1 antibody (C-10) enables valuable insights into the role of COL23A1 in cellular adhesion and tissue homeostasis, making this antibody an essential tool for studies focused on connective tissue biology and related disorders.

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COL23A1 Antibody (C-10) References:

1. Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells.  |  Banyard, J., et al. 2003. J Biol Chem. 278: 20989-94. PMID: 12644459
2. Expression of type XXIII collagen mRNA and protein.  |  Koch, M., et al. 2006. J Biol Chem. 281: 21546-21557. PMID: 16728390
3. Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment.  |  Veit, G., et al. 2007. J Biol Chem. 282: 27424-27435. PMID: 17627939
4. The collagens of articular cartilage.  |  Eyre, DR. 1991. Semin Arthritis Rheum. 21: 2-11. PMID: 1796302
5. The cartilage collagens: structural and metabolic studies.  |  Eyre, DR., et al. 1991. J Rheumatol Suppl. 27: 49-51. PMID: 2027130
6. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL23A1 Antibody (C-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COL23A1 Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL23A1 Antibody (C-10) Specifications

Alternate Product Name: COL23A1

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 70-86

Epitope Target: Collagen α1 Type XXIII

Epitope Species: human

Product Reactivity/Detection: COL23A1 isoform 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COL23A1 Antibody (C-10): P: Blocking Peptide