CNTD2 Inhibitors
CNTD2 inhibitors, though not recognized by a singular chemical class, are diverse compounds that interact with various cellular components and pathways to indirectly inhibit the function of CNTD2. These chemical compounds operate through different mechanisms that converge on the common outcome of disrupting the intracellular milieu and transport mechanisms essential for CNTD2 activity. For instance, agents that target the cytoskeletal elements, such as colchicine and paclitaxel, exert their effects by destabilizing or overly stabilizing the microtubule network. This alteration in microtubule dynamics can hinder the intracellular trafficking of CNTD2, thus preventing it from reaching the subcellular locations where it is active or from interacting with other proteins that are necessary for its function.
Blebbistatin and other actin cytoskeleton-affecting drugs work by disrupting the dynamics of actin filaments. The cytoskeleton, composed of microtubules and actin filaments, is essential for the trafficking and localization of cellular components, including proteins like CNTD2. By impeding myosin II ATPase activity, blebbistatin prevents myosin from generating the force necessary for muscle contraction and other forms of cellular movement. This impacts cellular processes such as cytokinesis, cell shape maintenance, and the movement of vesicles and organelles within the cell. Consequently, the proper distribution and function of CNTD2 within the cell can be compromised, leading to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, one of the main constituents of microtubules, preventing its polymerization and thus leading to the depolymerization of microtubules. As CNTD2 requires proper microtubule formation for its intracellular trafficking and function, colchicine's action would result in the improper localization of CNTD2, therefore inhibiting its function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can disrupt the dynamic reorganization of the microtubule network that is essential for the normal trafficking and function of CNTD2. This stabilization can thus indirectly inhibit the proper functioning of CNTD2 by impeding its correct cellular localization. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin inhibits myosin II activity, which is crucial for muscle contraction and cell motility that are dependent on the actin cytoskeleton. The inhibition of myosin II can thereby hinder the actin-dependent movement of CNTD2 to its functional sites within the cell, leading to its inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK, a kinase that phosphorylates myosin light chain to promote actin-myosin contraction. Inhibition of ROCK leads to reduced cell contractility, potentially disrupting the cellular processes that facilitate the proper localization and function of CNTD2. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC 23766 inhibits the Rac1 GTPase, impacting cell adhesion and migration. Since Rac1 is involved in the regulation of the actin cytoskeleton, NSC 23766 can indirectly inhibit the functional activity of CNTD2 by interfering with its cellular distribution. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the regulation of the actin cytoskeleton and cellular contraction. By inhibiting MLCK, ML-7 can disrupt the actin cytoskeleton dynamics, possibly inhibiting the movement and localization of CNTD2 within the cell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. MEK inhibition can lead to reduced phosphorylation and activation of downstream proteins, which can affect cellular processes that are required for the proper functioning of CNTD2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can disrupt several signaling pathways, including those involved in cell growth and movement, which may be required for the functional activity of CNTD2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that can disrupt signaling pathways important for cellular processes such as growth, survival, and trafficking, potentially leading to the indirect inhibition of CNTD2 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is an inhibitor of p38 MAPK, a protein kinase involved in response to stress and inflammatory cytokines. Inhibition of p38 MAPK can affect the signaling pathways which may be necessary for the proper function and localization of CNTD2. | ||||||