CLPTM1 Activators
Chemical activators of CLPTM1 may involve compounds that interact with cellular membranes, influencing the biophysical properties that are crucial for scramblase function. Calcium ionophores such as Ionomycin and A23187 can increase intracellular calcium concentrations, which are known to activate scramblase activity. This elevation in calcium can act as a signal to prompt scramblase enzymes to catalyze the translocation of phospholipids across the lipid bilayer, an activity that CLPTM1 is presumed to conduct. Progesterone and other membrane-integrating molecules offer an alternative route to modulation by embedding within the lipid bilayer, changing the environment in which CLPTM1 operates, possibly leading to altered scramblase activity.
In addition, unsaturated fatty acids like Oleic and Linoleic Acid have the ability to disrupt the orderly packing of lipid tails within the membrane, potentially enhancing the fluidity and creating a more conducive environment for the scramblase activity of CLPTM1. On the contrary, cholesterol is known to exert a rigidifying effect on membranes, which could also affect scramblase function by altering the physical state of the lipid bilayer. Furthermore, specific ionophores and channel blockers, such as Valinomycin and Verapamil, respectively, offer indirect methods of altering scramblase activity by modulating ion gradients and intracellular signaling pathways that can influence scramblase function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that can increase intracellular calcium levels, which is known to activate calcium-dependent scramblases and may thus promote CLPTM1 activity if it operates in a calcium-dependent manner. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Another calcium ionophore similar to Ionomycin, raising intracellular calcium and potentially activating calcium-dependent lipid scramblases. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
A steroid hormone that can integrate into the membrane and may influence membrane fluidity, potentially affecting the activity of membrane-associated enzymes like scramblases. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
A polar aprotic solvent that can permeate biological membranes and may influence membrane fluidity, possibly affecting CLPTM1 activity indirectly. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
An unsaturated fatty acid that integrates into cellular membranes, altering fluidity and potentially modulating the activity of membrane proteins including scramblases. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
Another unsaturated fatty acid that, similar to Oleic Acid, can be incorporated into membranes and affect the function of proteins like CLPTM1. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
A key component of cellular membranes that can rigidify the membrane, potentially influencing scramblase activity by altering the biophysical properties of the lipid bilayer. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
A calcium channel blocker that can influence intracellular calcium levels and indirectly affect the activation of calcium-dependent lipid scramblases. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
A potassium ionophore that disrupts ion gradients across the membrane, which can influence cellular signaling pathways and potentially scramblase activity. | ||||||
Amphotericin B | 1397-89-3 | sc-202462 sc-202462A sc-202462B | 100 mg 500 mg 1 g | $69.00 $139.00 $219.00 | 10 | |
An antifungal agent that binds to sterols in the membrane, altering membrane permeability and potentially influencing the function of membrane-associated proteins like CLPTM1. | ||||||