Clpb Inhibitors
Clpb inhibitors are chemical compounds that target and inhibit the activity of Clpb, a protein belonging to the AAA+ (ATPases Associated with diverse cellular Activities) family. Clpb, also known as ClpB, is a molecular chaperone that plays a crucial role in protein quality control within the cell, particularly in the reactivation and disaggregation of misfolded proteins. This protein works in conjunction with other chaperones such as DnaK and ClpC to refold denatured or aggregated proteins, maintaining protein homeostasis under conditions of cellular stress, such as heat shock. Clpb's function is critical for preventing the accumulation of insoluble protein aggregates, which can interfere with cellular processes. Inhibitors of Clpb block its ATPase activity, which is necessary for driving the mechanical processes involved in protein disaggregation, thereby disrupting the protein quality control machinery.
The mechanism of Clpb inhibitors involves binding to the ATP-binding domain of the protein, preventing ATP hydrolysis, which is essential for its chaperone activity. By inhibiting Clpb's ability to use energy from ATP to disaggregate and refold proteins, these inhibitors interfere with the normal cellular response to stress conditions that result in protein misfolding. Studying Clpb inhibitors provides researchers with insights into the processes of protein folding, degradation, and the maintenance of proteostasis in cells. Since Clpb is part of a broader system of molecular chaperones, inhibiting its function also offers a way to explore the interplay between different chaperone systems and their roles in cellular stress responses. This helps in understanding how cells manage protein damage and sustain functionality in challenging environmental conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP is an uncoupler of oxidative phosphorylation in mitochondria. By disrupting the proton gradient across the inner mitochondrial membrane, it can indirectly inhibit CHCHD1, a protein located in the intermembrane space of mitochondria, by altering the proper mitochondrial membrane potential necessary for its activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits the electron transport chain by blocking the transfer of electrons from cytochrome b to cytochrome c1. This can lead to a decrease in the mitochondrial membrane potential, which can indirectly inhibit the function of CHCHD1. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase, leading to a reduction in the mitochondrial membrane potential. This can indirectly inhibit CHCHD1 by altering the mitochondrial membrane potential necessary for its activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP is a protonophore and uncoupler of oxidative phosphorylation in mitochondria. By disrupting the proton gradient across the inner mitochondrial membrane, it can indirectly inhibit CHCHD1 by altering the mitochondrial membrane potential necessary for its activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of complex I in the electron transport chain. This can lead to a decrease in the mitochondrial membrane potential, which can indirectly inhibit the function of CHCHD1. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain, which can lead to a decrease in the mitochondrial membrane potential. This decrease can indirectly inhibit CHCHD1 by altering the mitochondrial environment necessary for its activity. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA is an inhibitor of succinate dehydrogenase, a component of complex II in the electron transport chain. The inhibition of electron transport can decrease the mitochondrial membrane potential, indirectly inhibiting CHCHD1. | ||||||
DCC | 538-75-0 | sc-239713 sc-239713A | 25 g 100 g | $71.00 $204.00 | 3 | |
DCCD is an inhibitor of the ATP synthase proton channel, disrupting the proton gradient across the inner mitochondrial membrane. This can indirectly inhibit CHCHD1 by altering the mitochondrial membrane potential necessary for its activity. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is a potassium ionophore that disrupts the mitochondrial membrane potential. The disruption can indirectly inhibit CHCHD1 by altering the mitochondrial environment necessary for its activity. | ||||||